Effects of zinc supplementation on markers of insulin resistance and lipid Profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial

Foroozanfard, F. and Jamilian, M. and Jafari, Z. and Khassaf, A. and Hosseini, A. and Khorammian, H. and Asemi, Z. (2015) Effects of zinc supplementation on markers of insulin resistance and lipid Profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Experimental and Clinical Endocrinology and Diabetes, 123 (4). pp. 215-220.

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Abstract

Objective: This study was conducted to evaluate the effects of zinc supplementation on glucose homeostasis parameters and lipid concentrations in PCOS women. We are aware of no study evaluating the effects of zinc supplementation on metabolic profiles of patients with polycystic ovary syndrome (PCOS). Methods: This randomized, double-blind, placebo-controlled trial was conducted among 52 women diagnosed with PCOS and aged 18-40 years old. Participants were randomly divided into 2 groups to receive 220mg zinc sulfate (containing 50mg zinc) supplements (n=26) or placebo (n=26) per day for 8 weeks. Fasting blood samples were taken at baseline and after 8 weeks' intervention to quantify glucose, insulin and lipid concentrations. Results: After 8 weeks of intervention, subjects who received zinc supplements had significantly increased serum zinc levels (+15.6±21.8 vs. -4.1±16.7mg/dL, P=0.001) compared with placebo. In addition, zinc-supplemented patients had reduced fasting plasma glucose (FPG) (-4.3±9.6 vs. +0.5±6.0mg/dL, P=0.03), serum insulin levels (-3.0±2.9 vs. +1.5±8.4μIU/mL, P=0.01), homeostasis model of assessment-insulin resistance (HOMA-IR) (-0.8±0.8 vs. +0.3±1.9, P=0.006), homeostatic model assessment-Beta cell function (HOMA-B) (-10.6±9.5 vs. +4.9±32.1, P=0.02) and increased quantitative insulin sensitivity check index (QUICKI) (+0.02±0.02 vs. -0.004±0.05, P=0.03) compared with placebo. Additionally, a significant reduction in serum triglycerides (-15.6±40.3 vs. +14.5±25.3mg/dL, P=0.002) and VLDL-cholesterol concentrations (-3.2±8.1 vs. +2.9±5.1 mg/dL, P=0.002) was observed following the administration of zinc supplements compared with placebo. Conclusion: Taken together, 220 mg zinc sulfate supplementation per day for 8 weeks among PCOS women had beneficial effects on metabolic profiles. J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: glucose; insulin; placebo; triacylglycerol; very low density lipoprotein cholesterol; zinc; zinc sulfate; biological marker; glucose blood level; insulin; lipid; zinc sulfate, absence of side effects; adult; Article; blood sampling; cholesterol blood level; controlled study; diet restriction; double blind procedure; female; glucose blood level; glucose homeostasis; human; insulin blood level; insulin resistance; lipid analysis; major clinical study; ovary polycystic disease; pancreas islet beta cell; pancreas islet cell function; priority journal; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; supplementation; triacylglycerol blood level; zinc blood level; adolescent; blood; diet supplementation; insulin resistance; metabolism; physiology; Polycystic Ovary Syndrome; treatment outcome; young adult, Adolescent; Adult; Biomarkers; Blood Glucose; Dietary Supplements; Double-Blind Method; Female; Humans; Insulin; Insulin Resistance; Lipids; Polycystic Ovary Syndrome; Treatment Outcome; Young Adult; Zinc Sulfate
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 17:13
Last Modified: 07 Mar 2017 17:13
URI: http://eprints.kaums.ac.ir/id/eprint/283

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