Effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes: Randomized, double-blind, placebo-controlled trial

Samimi, M. and Jamilian, M. and Asemi, Z. and Esmaillzadeh, A. (2015) Effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes: Randomized, double-blind, placebo-controlled trial. Clinical Nutrition, 34 (3). pp. 388-393.

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Abstract

Background & aims: We are aware of no study that examined the effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes (GDM). This study was designed to assess the effects of omega-3 fatty acid supplementation on insulin concentrations and lipid profiles among pregnant women with GDM. Methods: This randomized, double-blind, placebo-controlled clinical trial was performed among 56 women with GDM. Subjects were randomly assigned to receive either 1000mg omega-3 fatty acid supplements containing 180mg eicosapentaenoic acid and 120mg docosahexanoic acid (n=28) or placebo (n=28) for 6 weeks. Fasting blood samples were taken at study baseline and after 6 weeks of intervention to quantify biochemical variables. Results: Although omega-3 fatty acid supplementation did not led to a significant change in serum insulin levels and HOMA-IR in omega-3 fatty acid group, we found a significant difference in changes in serum insulin levels (change from baseline:-1.5±7.5 vs.+3.5±8.5μIU/mL, P=0.02) and HOMA-IR (-0.4±2.1 vs.+1.1±2.4, P=0.02) comparing the two groups. Furthermore, a significant reduction in serum high sensitivity C-reactive protein (hs-CRP) levels was seen after omega-3 fatty acid supplementation compared with placebo (-236.3±1541.9 vs. 898.6±2292.7ng/mL, P=0.03). Omega-3 fatty acid supplementation did not influence fasting plasma glucose, homeostatic model assessment-Beta cell function (HOMA-B), quantitative insulin sensitivity check index (QUICKI) and lipid profiles. Conclusions: Omega-3 fatty acid supplementation in GDM women had beneficial effects on insulin resistance, however, it did not affect plasma glucose, HOMA-B, QUICKI and lipid profiles. Clinical registration number: www.irct.ir as IRCT201312265623N16. © 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.

Item Type: Article
Additional Information: cited By 8
Uncontrolled Keywords: C reactive protein; docosahexaenoic acid; glucose; high density lipoprotein cholesterol; icosapentaenoic acid; insulin; lipid; low density lipoprotein cholesterol; omega 3 fatty acid; placebo; triacylglycerol; antioxidant; C reactive protein; glucose blood level; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; omega 3 fatty acid; triacylglycerol, adult; Article; blood sampling; clinical assessment tool; controlled clinical trial; controlled study; diet supplementation; double blind procedure; drug efficacy; drug mechanism; drug protein binding; drug targeting; female; glucose blood level; homeostasis model of assessment insulin resistance score; homeostatic model assessment beta cell function; human; insulin blood level; insulin metabolism; insulin resistance; intervention study; lipid analysis; lipid blood level; lipid metabolism; major clinical study; patient compliance; pregnancy diabetes mellitus; protein degradation; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; treatment duration; adolescent; blood; body mass; body weight; Diabetes, Gestational; diet restriction; insulin resistance; Iran; metabolism; pregnancy; young adult, Adolescent; Adult; Antioxidants; Blood Glucose; Body Mass Index; Body Weight; C-Reactive Protein; Cholesterol, HDL; Cholesterol, LDL; Diabetes, Gestational; Dietary Supplements; Double-Blind Method; Fasting; Fatty Acids, Omega-3; Female; Humans; Insulin; Insulin Resistance; Iran; Pregnancy; Triglycerides; Young Adult
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 17:15
Last Modified: 07 Mar 2017 17:15
URI: http://eprints.kaums.ac.ir/id/eprint/278

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