Effect of the cumin cyminum L. intake on weight loss, metabolic profiles and biomarkers of oxidative stress in overweight subjects: A randomized double-blind placebo-controlled clinical trial

Taghizadeh, M. and Memarzadeh, M.R. and Asemi, Z. and Esmaillzadeh, A. (2015) Effect of the cumin cyminum L. intake on weight loss, metabolic profiles and biomarkers of oxidative stress in overweight subjects: A randomized double-blind placebo-controlled clinical trial. Annals of Nutrition and Metabolism, 66 (2-3). pp. 117-124.

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Abstract

Background: The current study was performed to determine the effects of cumin cyminum L. intake on weight loss and metabolic profiles among overweight subjects. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 78 overweight subjects (male, n = 18; female, n = 60) aged 18-60 years old. Participants were randomly assigned into three groups to receive: (1) cumin cyminum L. capsule (n = 26); (2) orlistat120 capsule (n = 26) and (3) placebo (n = 26) three times a day for 8 weeks. Anthropometric measures and fasting blood samples were taken at baseline and after 8 weeks of intervention. Results: Consumption of the Cuminum cyminum L. and orlistat120 resulted in a similar significant decrease in weight (-1.1 ± 1.2 and -0.9 ± 1.5 vs. 0.2 ± 1.5 kg, respectively, p = 0.002) and BMI (-0.4 ± 0.5 and -0.4 ± 0.6 vs. 0.1 ± 0.6 kg/m2, respectively, p = 0.003) compared with placebo. In addition, taking Cuminum cyminum L., compared with orlistat and placebo, led to a significant reduction in serum insulin levels (-1.4 ± 4.5 vs. 1.3 ± 3.3 and 0.3 ± 2.2 μIU/ml, respectively, p = 0.02), HOMA-B (-5.4 ± 18.9 vs. 5.8 ± 13.3 and 1.0 ± 11.0, respectively, p = 0.02) and a significant rise in QUICKI (0.01 ± 0.01 vs. -0.005 ± 0.01 and -0.004 ± 0.01, respectively, p = 0.02). Conclusion: Taking cumin cyminum L. for eight weeks among overweight subjects had the same effects of orlistat120 on weight and BMI and beneficial effects on insulin metabolism compared with orlistat120 and placebo. © 2015 S. Karger AG, Basel.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: biological marker; essential oil; insulin; placebo; tetrahydrolipstatin; thyroid hormone; biological marker; glutathione; insulin; lactone; tetrahydrolipstatin, adult; Article; body mass; body weight; controlled study; cumin; double blind procedure; drug effect; female; glucose homeostasis; human; insulin blood level; insulin metabolism; major clinical study; male; obesity; oxidative stress; priority journal; randomized controlled trial; weight reduction; blood; Cuminum; diet; Iran; metabolome; middle aged; Overweight; phytotherapy, Cuminum cyminum, Adult; Biomarkers; Body Mass Index; Cuminum; Diet; Double-Blind Method; Female; Glutathione; Humans; Insulin; Iran; Lactones; Male; Metabolome; Middle Aged; Overweight; Oxidative Stress; Phytotherapy; Placebos; Weight Loss
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 17:15
Last Modified: 07 Mar 2017 17:15
URI: http://eprints.kaums.ac.ir/id/eprint/275

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