Evaluation of an auditory brainstem response in icteric neonates

Talebian, A. and Jahangiri, M. and Sharif, M.R. and Moraveji, S.A. and Kheirkhah, D. and Ghorbani, M. and Hojjati, M. and Talebian, M. (2017) Evaluation of an auditory brainstem response in icteric neonates. Feyz Journal of Kashan University of Medical Sciences, 21 (3). pp. 292-297.


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Background: Neonatal hyperbilirubinemia is a common and preventable cause of sensory-neural hearing impairment, which can cause difficulties in the development of speech and communication. This study was conducted to detect the toxic effect of hyperbilirubinemia on the brain stem and auditory tract in neonates with icterus admitted to Shahid Beheshti Hospital in Kashan, Iran. Materials and Methods: This cross-sectional study was conducted on 98 neonates with increased indirect bilirubin admitted to Shahid Beheshti Hospital in Kashan during 2014-2015. The patients were referred to Matini Hospital for the assessment of the auditory brainstem response (ABR); wave latency and interpeak intervals of the waves were also evaluated. According to the serum bilirubin level, the neonates were allocated into two groups; one group had a serum bilirubin level of 13-20 mg/d and another group had a bilirubin level more than 20 mg/d. Results: From 98 neonates, 26 (26.5) had a bilirubin level more than 20 mg/d and 72 (73.5) had a bilirubin level of 13-20 mg/d. Also, 46.1 of the neonates in the first group (bilirubin< 20 mg/d) and 2.8 of the neonates in the second group (bilirubin 13-20 mg/d) had abnormal ABR (P<0.0001). There was a significant difference between the mean latency time of III and V waves and the interpeak intervals of I-III, I-V, and III-V waves in neonates of the two groups (P<0.05). Conclusion: An increased indirect bilirubin level (>20 mg/d) can cause an auditory processing disorder in neonates. So, performing ABR for screening and early detection of bilirubin toxicity can be recommended as a necessary audiologic intervention in all cases of severe neonatal hyperbilirubinemia.

Item Type: Article
Subjects: Medicine
Divisions: Feyz journal
Depositing User: editor . feyz
Date Deposited: 08 Aug 2017 15:44
Last Modified: 15 Aug 2017 16:24
URI: http://eprints.kaums.ac.ir/id/eprint/2749

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