The effect of multi mineral-vitamin D supplementation on pregnancy outcomes in pregnant women at risk for pre-eclampsia

Asemi, Z. and Esmaillzadeh, A. (2015) The effect of multi mineral-vitamin D supplementation on pregnancy outcomes in pregnant women at risk for pre-eclampsia. International Journal of Preventive Medicine, 2015 (JULY).

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Background: The objective of this study was to determine the favorable effects of multi mineral�Vitamin D supplementation on pregnancy outcomes among women at risk for pre�eclampsia. Methods: This randomized double�blind controlled clinical trial was conducted among 46 women at risk for pre�eclampsia at 27 weeks� gestation with positive roll-over test. Pregnant women were randomly assigned to receive either the multi mineral�Vitamin D supplements (n = 23) or the placebo (n = 23) for 9�week. Multi mineral�Vitamin D supplements were containing 800 mg calcium, 200 mg magnesium, 8 mg zinc, and 400 IU Vitamin D3. Fasting blood samples were taken at baseline and after 9�week intervention to measure related factors. Newborn�s outcomes were determined. Results: Although no significant difference was seen in newborn�s weight and head circumference between the two groups, mean newborns� length (51.3 ± 1.7 vs. 50.3 ± 1.2 cm, P = 0.03) was significantly higher in multi mineral�Vitamin D group than that in the placebo group. Compared to the placebo, consumption of multi mineral�Vitamin D supplements resulted in increased levels of serum calcium (+0.19 vs. �0.08 mg/dL, P = 0.03), magnesium (+0.15 vs. �0.08 mg/dL, P = 0.03), zinc (+8.25 vs. �21.38 mg/dL, P = 0.001) and Vitamin D (+3.79 vs. �1.37 ng/ml, P = 0.01). In addition, taking multi mineral�Vitamin D supplements favorably influenced systolic blood pressure (SBP) (�1.08 vs. 6.08 mmHg, P = 0.001) and diastolic blood pressure (DBP) (�0.44 vs. 3.05 mmHg, P = 0.02). Conclusions: Multi mineral�Vitamin D supplementation for 9�week in pregnant women at risk for pre�eclampsia resulted in increased newborn�s length, increased circulating levels of maternal serum calcium, magnesium, zinc and Vitamin D, and led to decreased maternal SBP and DBP. © 2015 Asemi Z.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: calcium; colecalciferol; ferrous sulfate; folic acid; magnesium; mineral; placebo; zinc, adult; Article; birth weight; blood sampling; body height; calcium blood level; cardiovascular risk; clinical article; colecalciferol blood level; controlled study; diastolic blood pressure; diet restriction; double blind procedure; drug effect; female; gestation period; head circumference; human; magnesium blood level; mineral supplementation; newborn; preeclampsia; pregnancy outcome; pregnant woman; randomized controlled trial; systolic blood pressure; treatment duration; vitamin blood level; vitamin supplementation; zinc blood level
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 14:20
Last Modified: 08 Mar 2017 14:20

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