Case report of a patient with paroxysmal nocturnal hemoglobinuria during pregnancy

Mahdizadeh, A. and Akbarian, A. and Movahedi, H.A. and Arjmand, F. and Alaghehbandan, R. (1999) Case report of a patient with paroxysmal nocturnal hemoglobinuria during pregnancy. Feyz Journal of Kashan University of Medical Sciences, 3.

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Official URL: http://feyz.kaums.ac.ir/article-1-517-en.html

Abstract

History and Objectives: PNH is a rare nonhereditary hemolytic anemia characterized by acute and chronic intravascular hemolysis and recurrent hemoglobinuria. It often results in abortion and vascular complications such as venous thrombosis but some cases of successful and uncomplicated pregnancies have been observed in these patients. In this way, a pregnant patient with PNH, referred to Rasool Akram hospital in Tehran in winter of 1377 is reported. Case report and Findings: The patient was a 22-year-old G2P1 woman with a 34-weeks gestation fetus who has referred to hospital because of preeclampsia. Manifestations of PNH were progressively presented during her second pregnancy. After hospitalization, cesarean section was performed and a preterm female newborn was delivered. Postoperatively, the patient developed venous thrombosis in the abdominal wall vessels. After improvement she was discharged from the hospital in a satisfactory general condition. Conclusion: Venous thrombosis in pregnant PNH patients during pregnancy and postpartum period is hazardous unless treated. Monitoring of hemoglobin and hematocrit levels, timely blood transfusion and evaluation of coagulation system activity are important factors in prognosis.

Item Type: Article
Subjects: Midwifery
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 15 May 2017 14:47
Last Modified: 22 May 2017 15:23
URI: http://eprints.kaums.ac.ir/id/eprint/2613

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