Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial

Asemi, Z. and Jamilian, M. and Mesdaghinia, E. and Esmaillzadeh, A. (2015) Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial. Nutrition, 31 (10). pp. 1235-1242.

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Objective: To our knowledge, no reports are available indicating the effects of selenium supplementation on metabolic parameters, inflammatory factors, and oxidative stress in gestational diabetes mellitus (GDM). The aim of this study was to assess the effects of selenium supplementation on metabolic status in pregnant women with GDM who were not on oral hypoglycemic agents. Methods: This randomized, double-blind, placebo-controlled clinical trial was performed with 70 women with GDM. Patients were randomly assigned to receive either 200 μg selenium supplements as tablet (n = 35) or placebo (n = 35) for 6 wk from weeks 24 to 28 of gestation. Fasting plasma samples were taken at study baseline and after 6 wk of intervention to quantify related variables. Results: Selenium supplementation, compared with placebo, resulted in a significant reduction in fasting plasma glucose (-10.5 ± 11.9 versus +4.5 ± 12.9 mg/dL; P < 0.001), serum insulin levels (-1.98 ± 11.25 versus +5.26 ± 9.33 μIU/mL; P = 0.005), homeostasis model of assessment (HOMA)-insulin resistance (-0.84 ± 2.76 versus +1.47 ± 2.46; P < 0.001) and a significant increase in quantitative insulin sensitivity check index (+0.008 ± 0.03 versus -0.01 ± 0.01; P = 0.009). Additionally, a significant decrease in serum high-sensitivity C-reactive protein (hs-CRP) levels (-791.8 ± 2271.8 versus +500.5 ± 2563.3 ng/mL; P = 0.02) was seen after the administration of selenium supplements compared with placebo. Additionally, we observed a significant elevation in plasma glutathione (+52.14 ± 58.31 versus -39.93 ± 153.52 μmol/L; P = 0.002) and a significant reduction in plasma malondialdehyde levels (-0.01 ± 0.36 versus +0.67 ± 1.90 μmol/L; P = 0.04) after consumption of selenium supplements compared with placebo. We did not find any significant effect of taking selenium supplements on HOMA β-cell function, lipid profiles, plasma nitric oxide, or total antioxidant capacity concentrations. Conclusion: Selenium supplementation in pregnant women with GDM demonstrated beneficial effects on glucose metabolism, hs-CRP levels, and biomarkers of oxidative stress. © 2015 Elsevier Inc.

Item Type: Article
Additional Information: cited By 8
Uncontrolled Keywords: alpha tocopherol; ascorbic acid; C reactive protein; cholesterol; glucose; glutathione; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; magnesium; malonaldehyde; monounsaturated fatty acid; nitric oxide; placebo; polyunsaturated fatty acid; retinol; saturated fatty acid; selenium; triacylglycerol; antioxidant; C reactive protein; glucose blood level; glutathione; selenium, adult; anthropometric parameters; antioxidant activity; Article; body height; caloric intake; carbohydrate intake; cesarean section; clinical assessment; controlled study; diastolic blood pressure; diet supplementation; dietary fiber; dietary intake; double blind procedure; fat intake; female; glucose blood level; glucose homeostasis; glucose intolerance; glucose metabolism; glutathione metabolism; head circumference; human; inflammation; insulin blood level; insulin resistance; insulin sensitivity; intention to treat analysis; intervention study; Iran; major clinical study; metabolic parameters; neonatal hyperbilirubinemia; newborn; oral glucose tolerance test; oxidative stress; physical activity; pregnancy diabetes mellitus; pregnant woman; priority journal; protein intake; randomized controlled trial; systolic blood pressure; blood; Diabetes, Gestational; diet restriction; dietary supplement; drug effects; homeostasis; oxidative stress; pregnancy, Adult; Antioxidants; Blood Glucose; C-Reactive Protein; Diabetes, Gestational; Dietary Supplements; Double-Blind Method; Fasting; Female; Glutathione; Homeostasis; Humans; Insulin Resistance; Oxidative Stress; Pregnancy; Selenium
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 14:25
Last Modified: 08 Mar 2017 14:25
URI: http://eprints.kaums.ac.ir/id/eprint/259

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