The favourable effects of long-term selenium supplementation on regression of cervical tissues and metabolic profiles of patients with cervical intraepithelial neoplasia: A randomised, double-blind, placebo-controlled trial

Karamali, M. and Nourgostar, S. and Zamani, A. and Vahedpoorfard, Z. and Asemi, Z. (2015) The favourable effects of long-term selenium supplementation on regression of cervical tissues and metabolic profiles of patients with cervical intraepithelial neoplasia: A randomised, double-blind, placebo-controlled trial. British Journal of Nutrition, 114 (12). pp. 2039-2045.

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Abstract

This study was conducted to assess the effects of long-term Se administration on the regression and metabolic status of patients with cervical intraepithelial neoplasia grade 1 (CIN1). This randomised, double-blind, placebo-controlled trial was carried out among fifty-eight women diagnosed with CIN1. To diagnose CIN1, we used specific diagnostic procedures of biopsy, pathological diagnosis and colposcopy. Patients were randomly assigned to two groups to receive 200 μg Se supplements as Se yeast (n 28) or placebo (n 28) daily for 6 months. After 6 months of taking Se supplements, a greater percentage of women in the Se group had regressed CIN1 (88·0 v. 56·0 ; P=0·01) compared with those in the placebo group. Long-term Se supplementation, compared with the placebo, resulted in significant decreases in fasting plasma glucose levels (-0·37 (sd 0·32) v. +0·07 (sd 0·63) mmol/l; P=0·002), serum insulin levels (-28·8 (sd 31·2) v. +13·2 (sd 40·2) pmol/l; P<0·001), homeostatic model assessment of insulin resistance values (-1·3 (se 1·3) v. +0·5 (se 1·4); P<0·001) and a significant elevation in quantitative insulin sensitivity check index (+0·03 (sd 0·03) v. -0·01 (sd 0·01); P<0·001). In addition, patients who received Se supplements had significantly decreased serum TAG (-0·14 (sd 0·55) v. +0·15 (sd 0·38) mmol/l; P=0·02) and increased HDL-cholesterol levels (+0·13 (sd 0·21) v. -0·01 (sd 0·15) mmol/l; P=0·003). In addition, compared with the placebo group, there were significant rises in plasma total antioxidant capacity (+186·1 (sd 274·6) v. +42·8 (sd 180·4) mmol/l; P=0·02) and GSH levels (+65·0 (sd 359·8) v. -294·2 (sd 581·8) μmol/l; P=0·007) and a significant decrease in malondialdehyde levels (-1·5 (sd 2·1) v. +0·1 (sd 1·4) μmol/l; P=0·001) among those who took Se supplements. Overall, taking Se supplements among patients with CIN1 led to its regression and had beneficial effects on their metabolic profiles. © Copyright The Authors 2015.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: biological marker; C reactive protein; glucose; glutathione; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; malonaldehyde; nitric oxide; placebo; selenium; trace element; triacylglycerol; very low density lipoprotein cholesterol; selenium, absence of side effects; adult; Article; cancer regression; cholesterol blood level; colposcopy; controlled clinical trial; controlled study; diet supplementation; double blind procedure; female; glucose blood level; human; inflammation; insulin blood level; insulin metabolism; insulin resistance; insulin sensitivity; long term care; macronutrient; major clinical study; metabolism; oxidative stress; quantitative analysis; randomized controlled trial; tablet; triacylglycerol blood level; uterine cervix; uterine cervix biopsy; uterine cervix carcinoma in situ; middle aged; pathology; uterine cervix; uterine cervix carcinoma in situ, Adult; Cervical Intraepithelial Neoplasia; Cervix Uteri; Double-Blind Method; Female; Humans; Middle Aged; Placebos; Selenium
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 17:12
Last Modified: 07 Jun 2017 14:12
URI: http://eprints.kaums.ac.ir/id/eprint/258

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