Multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolated from patients in Kashan, Iran

Erami, M. and Soltani, B. and Taghavi-Ardakani, A. and Moravveji, S.A. and Moini, A.S. and Haji Rezaei, M. and Namazi, M. (2015) Multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolated from patients in Kashan, Iran. Jundishapur Journal of Microbiology, 8 (10).

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Abstract

Background: Escherichia coli and Klebsiella pneumoniae are common human pathogens that cause a wide spectrum of infections. Antimicrobial resistance is a basic obstacle in the management of these infections which has different patterns in various regions. Objectives: In this study, the antibiotic resistance patterns and risk factors for multidrug-resistant (MDR) E. coli and K. pneumoniae were determined. Patients and Methods: In this cross-sectional study, a total of 250 isolates (134 E. coli and 116 K. pneumoniae) were collected and antimicrobial resistances to ampicillin, amoxicillin-clavulanic acid, amikacin, gentamycin, ceftriaxone, ceftazidime, ciprofloxacin and imipenem were evaluated by disc diffusion method and confirmed by E-test. Moreover, risk factors for MDR E. coli and K. pneumoniae were also detected. Results: The mean ages of the culture-positive cases of E. coli and K. pneumoniae were 33.39 ± 24.42 and 36.54 ± 24.66 years, respectively (P = 0.31); 137 (54.8) cases were male and 113 (45.2) were female (P = 0.53). Nineteen (14.2) isolates of E. coli and 12 (10.3) isolates of K. pneumoniae were sensitive to all the evaluated antibiotics. The prevalence of MDR E. coli and MDR K. pneumoniae was 50 and 46.6, respectively (P = 0.59). The highest resistance for both strains was to ampicillin and no imipenem resistance was seen. The risk factors for MDR E. coli were admission history during the recent three months (P = 0.043) and antibiotic use in the previous month (P = 0.03); for MDR K. pneumoniae, they were admission in the pediatric ward (P = 0.016), surgical ward (P = 0.019), or gynecology ward (P = 0.12), admission duration of > seven days, and antibiotic use during the past month (P = 0.04). Conclusions: The prevalence of multidrug resistance was high compared with developed countries, and history of admission, antibiotic use, admission duration and admission wards were the risk factors for multidrug resistance. © 2015, Ahvaz Jundishapur University of Medical Sciences.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: amikacin; amoxicillin plus clavulanic acid; ampicillin; ceftazidime; ceftriaxone; ciprofloxacin; gentamicin; imipenem, adolescent; adult; aged; antibiotic sensitivity; Article; bacterium culture; bacterium detection; bacterium isolate; child; controlled study; cross-sectional study; disk diffusion; epsilometer test; Escherichia coli; female; hospital admission; human; Iran; Klebsiella pneumoniae; male; multidrug resistance; nonhuman; prevalence; risk factor
Subjects: Immunology and Microbiology
Divisions: Faculty of Medicine > Clinical Sciences > Department of Pediatrics
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 17:04
Last Modified: 08 Mar 2017 17:04
URI: http://eprints.kaums.ac.ir/id/eprint/254

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