Lavandula angustifolia extract improves deteriorated synaptic plasticity in an animal model of Alzheimer disease

Soheili-Kashani, M. and Rezaei-Tavirani, M. and Salami, M. (2015) Lavandula angustifolia extract improves deteriorated synaptic plasticity in an animal model of Alzheimer disease. Iranian Journal of Basic Medical Sciences, 18 (11). pp. 1147-1152.

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DOI: UNSPECIFIED

Abstract

synaptic transmission and synaptic plasticity. Long-term potentiation (LTP), an experimental form of synaptic plasticity, is intensively examined in hippocampus. In this study we evaluated the effect of aqueous extract of lavender (Lavandula angustifolia) on induction of LTP in the CA1 area of hippocampus. In response to stimulation of the Schaffer collaterals the baseline or tetanized field extracellular postsynaptic potentials (fEPSPs) were recorded in the CA1 area. Materials and Methods: The electrophysiological recordings were carried out in four groups of rats; two control groups including the vehicle (CON) and lavender (CE) treated rats and two Alzheimeric groups including the vehicle (ALZ) and lavender (AE) treated animals. Results: The extract inefficiently affected the baseline responses in the four testing groups. While the fEPSPs displayed a considerable LTP in the CON animals, no potentiation was evident in the tetanized responses in the ALZ rats. The herbal medicine effectively restored LTP in the AE group and further potentiated fEPSPs in the CE group. Conclusion: The positive effect of the lavender extract on the plasticity of synaptic transmission supports its previously reported behavioral effects on improvement of impaired spatial memory in the Alzheimeric animals. © 2015, Mashhad University of Medical Sciences. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Lavandula angustifolia extract; plant extract; unclassified drug, Alzheimer disease; animal experiment; animal model; Article; controlled study; electrophysiological procedures; high performance liquid chromatography; hippocampal CA1 region; Lavandula angustifolia; long term potentiation; male; nerve cell plasticity; nonhuman; postsynaptic potential; rat; spatial memory; synaptic transmission
Subjects: Neuroscience
Divisions: Faculty of Medicine > Basic Sciences > Department of physiology
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 17:06
Last Modified: 08 Mar 2017 17:06
URI: http://eprints.kaums.ac.ir/id/eprint/251

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