Correlation between serum YKL-40 and carotid intima media thickness in type 1 diabetics

Jafary, F. and Khamechi, S.P. and Talari, H.R. and Sharif, M.R. and Nikoueinejad, H. and Sehat, M. (2015) Correlation between serum YKL-40 and carotid intima media thickness in type 1 diabetics. International Journal of Diabetes in Developing Countries, 35. pp. 411-417.

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It has been suggested that elevated serum level of YKL-40 could be a risk factor as well as early marker of both type 2 and type 1 diabetes mellitus (T1D) and their complications. We investigated the correlation between serum level of YKL-40 and carotid intima media thickness (cIMT) as well as urinary albumin/creatinine ratio (UACR) in type 1 diabetic patients. A total of 49 patients with T1D and 43 healthy controls underwent the assessment of serum level of YKL-40 (by ELISA) and cIMT measurement (by Doppler ultrasonography). Fasting blood and urine samples were also taken to measure the levels of hemoglobin A1C, lipid profile, CBC, serum and urine creatinine, and urine albumin. Serum levels of YKL-40, cIMT, and UACR were significantly higher in diabetic patients compared to those in healthy people (P < 0.001). Serum levels of YKL-40 had a significant correlation with cIMT, and duration of diabetes. We report that YKL-40 may be a good prognostic as well as diagnostic marker of early macrovascular complications in T1D. © 2015, Research Society for Study of Diabetes in India.

Item Type: Article
Additional Information: cited By 0
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Internal Medicine
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 14:58
Last Modified: 12 Mar 2017 13:44

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