Effects of ramadan fasting on glucose homeostasis, lipid profiles, inflammation and oxidative stress in women with polycystic ovary syndrome in Kashan, Iran

Asemi, Z. and Samimi, M. and Taghizadeh, M. and Esmaillzadeh, A. (2015) Effects of ramadan fasting on glucose homeostasis, lipid profiles, inflammation and oxidative stress in women with polycystic ovary syndrome in Kashan, Iran. Archives of Iranian Medicine, 18 (12). pp. 806-810.

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Abstract

BACKGROUND: To our knowledge, no reports are available indicating the effects of Ramadan fasting on metabolic parameters, inflammatory factors and oxidative stress in polycystic ovary syndrome (PCOS). The current study was designed to evaluate the effects of Ramadan fasting on metabolic status among women with PCOS. METHODS: This cross-sectional study was conducted on twenty seven PCOS patients who had fasted for a mean period of 16.5 hours a day during the 29 days of the month of Ramadan in Kashan, Iran. Fasting blood samples were collected at the beginning of the study and after 29 days of the study to quantify related variables. To identify within-group differences (before and after Ramadan), paired-samples t-tests were used. RESULTS: Plasma nitric oxide (NO) levels in PCOS women after Ramadan fasting were significantly higher compared to the baseline values (70.63 ± 15.78 vs. 59.94 ± 13.87 μmol/L, P = 0.003). Post-Ramadan levels of plasma glutathione (GSH) increased significantly in comparison with pre-Ramadan (974.95 ± 414.20 vs. 746.96 ± 205.93 μmol/L, P = 0.011). In addition, a trend toward a significant effect of Ramadan fasting on reducing serum high sensitivity C-reactive protein (hs-CRP) concentrations (2001.07 ± 1686.08 vs. 2962.72 ± 2845.21 ng/mL, P = 0.072) was seen. We did not observe any significant effect of Ramadan fasting on glucose hemostasis parameters, lipid profiles or total antioxidant capacity (TAC). CONCLUSION: In conclusion, Ramadan fasting in women with PCOS for 4 weeks had beneficial effects on NO and GSH levels, but did not affect glucose hemostasis parameters, lipid profiles or TAC. © 2015, Academy of Medical Sciences of the I.R. Iran. All rights reserved.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: C reactive protein; glutathione; malonaldehyde; nitric oxide; antioxidant; biological marker; glucose blood level; glutathione; lipid; nitric oxide, adult; antioxidant activity; Article; clinical article; cross-sectional study; diet restriction; female; glucose blood level; glucose homeostasis; human; inflammation; Iran; lipid composition; ovary polycystic disease; oxidative stress; Quantitative Insulin Sensitivity Check Index; adolescent; blood; diet restriction; homeostasis; inflammation; Islam; metabolism; ovary polycystic disease; pathophysiology; physiology; young adult, Adolescent; Adult; Antioxidants; Biomarkers; Blood Glucose; Cross-Sectional Studies; Fasting; Female; Glutathione; Homeostasis; Humans; Inflammation; Iran; Islam; Lipids; Nitric Oxide; Oxidative Stress; Polycystic Ovary Syndrome; Young Adult
Subjects: Medicine
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 17:49
Last Modified: 08 Mar 2017 17:49
URI: http://eprints.kaums.ac.ir/id/eprint/243

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