Effect of Carotid arterial blockage on the water and specific gravity of rat brain

Verdi, J. and Nemat bakhsh, M. and Fakharian, E. (1997) Effect of Carotid arterial blockage on the water and specific gravity of rat brain. Feyz Journal of Kashan University of Medical Sciences, 1.

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Official URL: http://feyz.kaums.ac.ir/article-1-601-en.html
DOI: UNSPECIFIED

Abstract

History and Objectives: Due to the cerebral vasogenic edema and its effects on complications of blood brain barrier and its final effect on the function of brain and in order to determine the percentage of water and specific gravity of rat brain tissue in carotid arterial blockage, this in vitro study was conducted in 1994. Materials and Methods: An experimental clinical trial was conducted on 30 rats. Animals were divided into three groups and sodium thiopental (Nesdonal) (60 mg/kg) were injected intrapertioneally as an anesthetic agent. Carotid artery was blocked for 15 and 30 minutes in order to produce acute vasogenic edema. The effect of the blockage on the water percent and specific gravity of brain tissue was determined. Wet-dry method and specific gravity methods were used to measure the percentage of water and specific gravity. ANOVA test was used to analyze the results. Relationship between the blockage and water percentage and specific gravity of brain tissue was determined. Results: The present study showed that the percentage of water at 0, 15 and 30 minute intervals after edema at the right hemisphere of brain was 73.9%±5.3, 75.7%±2.5 and 77.1%±2.2 respectively, which was insignificant on statistical analysis. The percentages on the left hemisphere of the brain were 77.8%±1.4, 78.4%±3 and 80.6%±3 respectively, which was statistically significant. The specific gravity of right hemisphere was 1.046±0.001, 1.047±0.002 and 1.045±0.009 respectively, which was statistically significant. The specific gravity of the left hemisphere of the brain was 1.046±0.002, 1.044±0.002 and 1.043±0.003 respectively, which was statistically in significant. Conclusion: Linear regression of percentage of the water was W=73.96+10.37×10^-2 t for the right hemisphere and W=77.48+9.85×10^-2 t for the left hemisphere and for specific gravity of right and left hemisphere was 1/SG=0.956+4.005×10^-5 t and 1/SG=0.956+8.046×10^-5 t.

Item Type: Article
Subjects: Medicine
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 14 May 2017 15:25
Last Modified: 27 May 2017 17:37
URI: http://eprints.kaums.ac.ir/id/eprint/2422

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