Increased serum level of IL-37 in patients with multiple sclerosis and neuromyelitis optica

Farrokhi, M. and Rezaei, A. and Amani-Beni, A. and Etemadifar, M. and Kouchaki, E. and Zahedi, A. (2015) Increased serum level of IL-37 in patients with multiple sclerosis and neuromyelitis optica. Acta Neurologica Belgica, 115 (4). pp. 609-614.

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Abstract

Multiple sclerosis (MS) is a common autoimmune disease of central nervous system in which neurodegenerative and inflammatory mechanisms cause alternate neurological impairments. Many inflammatory and anti-inflammatory cytokines were suggested as contributor in MS pathogenesis, and the balance between these opposing cytokines can regulate MS severity. IL-37, an anti-inflammatory cytokine, is the most recently identified member of IL-1 family, which acts as a natural inhibitor of innate immunity. However, the role of IL-37 in MS has not investigated so far. Therefore, in this study, we aimed to measure serum level of IL-37 in patients with relapsing remitting multiple sclerosis (RRMS) and neuromyelitis optica (NMO). In a case�control study, plasma was collected from healthy controls (n = 49) and also patients with RRMS (n = 122) and NMO (n = 31). Serum level measurement of IL-37 was performed using enzyme-linked immunoassay (ELISA) method. The serum levels of IL-37 were 247.46 ± 74.02 and 312.00 ± 86.72 and 114.63 ± 20.58 in RRMS and NMO patients and healthy controls, respectively, showing statistically significant difference between them (P = 0.00). Furthermore, we found a positive correlation between the serum levels of IL-37 and EDSS of patients (r = +0.31 and P = 0.00). In summary, the serum level of IL-37 was found to be significantly increased in MS patients compared to healthy controls. Furthermore, the mean serum level of IL-37 was correlated with disease severity. This suggests that IL-37 may be part of a feed-back loop to control underlying inflammation in MS pathogenesis. However, further studies will be required to indicate exact role of IL-37 in the MS pathomechanisms. © 2015, Belgian Neurological Society.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: interleukin 37; IL37 protein, human; interleukin 1, adult; Article; case control study; controlled study; enzyme linked immunosorbent assay; female; human; major clinical study; male; multiple sclerosis; myelooptic neuropathy; nuclear magnetic resonance imaging; blood; disability; middle aged; multiple sclerosis; myelooptic neuropathy; statistics, Adult; Case-Control Studies; Disability Evaluation; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-1; Male; Middle Aged; Multiple Sclerosis; Neuromyelitis Optica; Statistics as Topic
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Clinical Sciences > Department of Internal Medicine
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 17:45
Last Modified: 08 Mar 2017 17:45
URI: http://eprints.kaums.ac.ir/id/eprint/237

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