Gender differences in a mouse model of chemotherapy-induced neuropathic pain

Naji-Esfahani, H. and Vaseghi, G. and Safaeian, L. and Pilehvarian, A.A. and Abed, A. and Rafieian-Kopaei, M. (2016) Gender differences in a mouse model of chemotherapy-induced neuropathic pain. Laboratory Animals, 50 (1). pp. 15-20.

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Chemotherapy-induced neuropathic pain is one of the major problems for cancer patients. Although paclitaxel and cisplatin are widely used in women, most laboratory studies of chemotherapy-induced neuropathic pain have been conducted on male animals. The current study examined the gender differences in chemotherapyinduced neuropathic pain in mice. Neuropathic pain was induced by intraperitoneal injection of paclitaxel (2 mg/kg) for five consecutive days and cisplatin (1 mg/kg) for seven consecutive days. Cold allodynia was evaluated by measuring the paw withdrawal frequency and duration of paw licking in mice; however, mechanical allodynia was assessed by von Frey filaments. Neuropathic pain began to manifest after a few days (P<0.001). Cold allodynia was more robust in female mice (P<0.001) treated with paclitaxel, while no differences were observed between the two genders in the manifestation of paclitaxel-induced mechanical allodynia. Interestingly, no gender differences were observed in cisplatin-induced cold and mechanical allodynia tests. In conclusion, gender differences play a major role in neuropathic pain induced by paclitaxel. The differences between male and female animals should be considered in future studies and the findings should be generalized to humans with caution. © The Author(s) 2015.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: cisplatin; paclitaxel, allodynia; animal behavior; animal experiment; animal model; Article; chemotherapy induced neuropathic pain; cold allodynia; controlled study; female; licking; male; mechanical stimulation; mouse; mouse model; neurologic disease assessment; neuropathic pain; nonhuman; paw; paw licking; paw withdrawal frequency; sex difference
Subjects: Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Basic Sciences > Department of Pharmacology
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 18:23
Last Modified: 08 Mar 2017 18:23

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