Effects of morphine with different dosage on pharmacodynamic alterations in patients undergoing abdominal surgery

Nafisi, Sh. and Farbod, A. (2004) Effects of morphine with different dosage on pharmacodynamic alterations in patients undergoing abdominal surgery. Feyz Journal of Kashan University of Medical Sciences, 8.

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Official URL: http://feyz.kaums.ac.ir/article-1-196-en.html
DOI: UNSPECIFIED

Abstract

Background: With respect to the known side effects of morphine and the necessity of morphine usage during surgery and also with respect to the controversies about the dosage of morphine, the present study was conducted on the patients undergoing abdominal surgery in Namazi hospital to compare the effects of morphine at the dosage of 0.1, 0.2, 0.3, and 0.4mg/kg.Materials and methods: This clinical trial was achieved on 82 patients with ASA class of I aged 20-50 years. Patients were randomly assigned in 4 groups. Having access the IV line 500ml ringer lactate was administered. Anesthetic-related medications were similar in all groups. The first group received 0.1mg/kg and the other groups received 0.2, 0.3, and 0.4mg/kg morphine. The effects of drug on heart rate, systolic and diastolic blood pressure was evaluated before the induction, 5, 10, and 15 minutes after the induction and results were compared using variance analysis.Results: Groups were matched according to the sex, age, type of surgery, and surgery duration. Groups did not show any significant difference in heart rate, systolic and diastolic blood pressure. During the first 10-hour in recovery room, there was not any significant difference between the groups regarding the pain occurrence. Increment in morphine dosage did not delay the pain-free duration.Conclusion: Different dosage of morphine did not influence on hemodynamic alterations. Thus, it is recommended to administer morphine at low dosage.

Item Type: Article
Subjects: Surgery
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 13 May 2017 16:39
Last Modified: 28 May 2017 12:09
URI: http://eprints.kaums.ac.ir/id/eprint/2265

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