Calcium plus Vitamin D supplementation affects pregnancy outcomes in gestational diabetes: Randomized, double-blind, placebo-controlled trial

Karamali, M. and Asemi, Z. and Ahmadi-Dastjerdi, M. and Esmaillzadeh, A. (2016) Calcium plus Vitamin D supplementation affects pregnancy outcomes in gestational diabetes: Randomized, double-blind, placebo-controlled trial. Public Health Nutrition, 19 (1). pp. 156-163.

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Abstract

Objective The present study was designed to assess the effects of Ca+vitamin D supplementation on pregnancy outcomes in women with gestational diabetes mellitus (GDM). Design A randomized, double-blind, placebo-controlled trial was conducted among sixty women with GDM. Participants were divided into two groups to receive Ca+vitamin D supplements or placebo. Individuals in the Ca+vitamin D group (n 30) received 1000 mg Ca/d and two pearls containing 1250 �g (50 000 IU) of cholecalciferol (vitamin D3) during the intervention (one at study baseline and another at day 21 of the intervention); those in the placebo group (n 30) received two placebos of vitamin D at the mentioned times and placebos of Ca every day for 6 weeks. Pregnancy outcomes were determined. Setting A urban community setting in Arak, Iran. Subjects Sixty women with GDM and their newborns, living in Arak, Iran were enrolled. Results Women treated with Ca+vitamin D had a significant decrease in caesarean section rate (23·3 v. 63·3 , P=0·002) and maternal hospitalization (0 v. 13·3 , P=0·03) compared with those receiving placebo. In addition, newborns of GDM women randomized to Ca+vitamin D had no case of macrosomia, while the prevalence of macrosomia among those randomized to placebo was 13·3 (P=0·03). Lower rates of hyperbilirubinaemia (20·0 v. 56·7 , P=0·03) and hospitalization (20·0 v. 56·7 , P=0·03) were also seen in the supplemented group of newborns than in the placebo group. Conclusions Ca+vitamin D supplementation for 6 weeks among pregnant women with GDM led to decreased caesarean section rate and maternal hospitalization, and decreased macrosomia, hyperbilirubinaemia and hospitalization in newborns. © 2015 The Authors.

Item Type: Article
Additional Information: cited By 1
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 18:26
Last Modified: 08 Mar 2017 18:26
URI: http://eprints.kaums.ac.ir/id/eprint/223

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