Surveying the effect of Androctonus crassicauda venom on clinical manifestations in rats

Dehghani, R. and Khamechian, T. and Asadi, M.A. (2006) Surveying the effect of Androctonus crassicauda venom on clinical manifestations in rats. Feyz Journal of Kashan University of Medical Sciences, 10.

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Background: Androctonus crassicauda is one of the dangerous scorpions in the world and also in Iran. This kind of scorpion in tropical regions stinges a lot of people resulting in dangerous side effects and sometimes death. The study of the effects of this scorpion venom on some laboratory animals can determine the rate of clinical manifestations and help us protect people stung by scorpion. So this study has been done to examine the effects of Androctonus crassicauda venom on r at. Materials and Methods: An experimental study has been done on 82 rats of the same race and with approximate age of 2-3 months, and 200-250 gr weight. 82 rats were divided into two groups: 40 in control and 42 in experimental group. 0.1cc physiologic serum was injected to each of the control group skin and 0.1 cc physiologic serum with one microlitre of fresh Androctonus crassicauda venom to each of experimental group. The clinical manifestations before death and mortality rates in two groups were compared and analyzed with statistical test of Fisher. Results: The injection of Androctonus crassicauda venom into rats caused the death of 88 of experimental group. The clinical manifestations were paralysis (66) irregular pulse (81), twitching (55), rhinorrhea (78.5), salivation (40.5), hemorrhage from eyes (71.5) and nosebleeds (52.5). Conclusion: Androctonus crassicauda venom has some roles in appearing clinical manifestations. The study of clinical manifestations in other laboratory animals can help to diagnose the effect of this venom in human being and find a suitable treatment for injured patients.

Item Type: Article
Subjects: Medicine
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 13 May 2017 12:12
Last Modified: 23 May 2017 13:17

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