Effect of garlic extract on gastric acid and pepsin secretion in rat

Shahrani, M. and Rafieian, M. and Shirzad, H. and Hashemzadeh, M. and Yoosefi, H. and Khadivi, R. and Amini, S.A. and Moradi, M.T. and Mogadasi, J. and Rahmani, M.R. (2007) Effect of garlic extract on gastric acid and pepsin secretion in rat. Feyz Journal of Kashan University of Medical Sciences, 10.

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Official URL: http://feyz.kaums.ac.ir/article-1-67-en.html


Background : Garlic (Allium sativum) is widely used as an additive in pickles around the world and particularly in Iran. Considering Garlic treatment function this study was conducted to survey the effect of this plant entrant on the secretion rate of acid and pepsin in the stomach. Materials and Methods: This study involves two groups of 12 rats (Control group and Garlic group). Animals were gone under anesthesia by nesdonal with 50 mg/kg IP and undertook surgical process, tracheotomy, laparatomy and gasteroadeodenostomy. Garlic extract 100 mg/kg was administered by gasterodeodenostomy canola. Tnyostric secretions, obtained in wash out way, 15 and 30 minutes after stress acid and pepsin were measured by Tetrameter and Anson aprooch, respectively. Results: The amount of acid in both bases was significantly increased in the garlic group compared to the control group (p<0.001). not significantly change was observed in pepsin secretion. The elevation of acid secretion had no significant relevance with sex. Conclusion: Garlic (Allium sativum) increases acid secretion when used in food regimen.

Item Type: Article
Subjects: Pharmacology, Toxicology and Pharmaceutics
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 11 May 2017 15:34
Last Modified: 22 May 2017 14:46
URI: http://eprints.kaums.ac.ir/id/eprint/2145

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