Effects of galbanum essential oil and mesna on skeletal teratogenicity induced by cyclophosphamide in rat fetuses

Mahabdy, M.K. and Varzi, H.N. and Taghizadeh, M. and Nemati, M. (2016) Effects of galbanum essential oil and mesna on skeletal teratogenicity induced by cyclophosphamide in rat fetuses. Journal of Mazandaran University of Medical Sciences, 25 (134). pp. 230-241.

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Background and purpose: Cyclophosphamide (CP) as a teratogen can lead to congenital abnormalities in animals and humans. Many reports have shown the influence of antioxidant drugs in reducing the adverse effects of CP. Galbanum has antioxidant effects and Mesna (Sodium 2mercaptoethane sulfonate) is used for decreasing the side effects of CP, especially hemorrhagic cystitis. This study aimed at investigating the effects of galbanum and mesna on cyclophosphamide-induced teratogenicity in rat fetuses. Materials and methods: This study was performed in 33 pregnant rats that were divided into five groups. A control group received normal saline and test groups received CP (15 mg/kg), CP plus mesna (100 mg/kg), CP plus galbanum (200 mg/kg) and CP plus mesna (100 mg/kg) plus galbanum (200 mg/kg) intraperitoneally on the 13th day of gestation, respectively. Fetuses were extracted on 20th day of gestation. Then, the weight and length of fetuses were measured and staining was done using Alizarin red - Alcian blue method. The teratogenic effects were investigated by stereomicroscope. Results: The results showed that the incidence of cleft palate, exencephaly, micromelia, and omphalocele were 37.50, 62.50, 16.62, and 9.37 in fetuses that received only CP which decreased to 28.57, 28.57, 3.57, and 7.14 in the group that had received CP plus mesna (75 mg/kg) and to 18.51, 14.81, 3.7, and 0 in the group which received CP plus galbanum (200 mg/kg), respectively. In treatment group that received CP plus mesna and galbanum the incidence of aforementioned abnormalities decreased to 18.64, 11.86, 3.38, and 0, respectively. Conclusion: In this study galbanum significantly decreased teratogenicity induced by CP. © 2016, Mazandaran University of Medical Sciences. All right reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: cyclophosphamide; essential oil; mesna, animal experiment; animal model; Article; cleft palate; controlled study; cyclophosphamide induced teratogenicity; cyclophosphamide induced teratogenicity; drug effect; drug induced disease; exencephaly; female; fetus; fetus weight; galbanum; micromelia; nonhuman; omphalocele; pregnancy; rat
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 21:25
Last Modified: 08 Mar 2017 21:25
URI: http://eprints.kaums.ac.ir/id/eprint/210

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