The frequency of AgNOR (Argyrophilic Nucleoli Organizer Region) points in differentiation between the benign prostatic hyperplasia and prostatic adenocarcinoma

Niazi, A. and Sheikhzadeh, A. and Narouie, B. and Moradi, H.R. (2009) The frequency of AgNOR (Argyrophilic Nucleoli Organizer Region) points in differentiation between the benign prostatic hyperplasia and prostatic adenocarcinoma. Feyz Journal of Kashan University of Medical Sciences, 13.

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Official URL: http://feyz.kaums.ac.ir/article-1-784-en.html
DOI: UNSPECIFIED

Abstract

Background: While the differentiation of prostatic adenocarcinoma and benign prostatic hyperplasia (BPH) is not often a difficult task, sometimes it is not the case even for the experienced pathologists. In this study the efficacy of AgNOR staining technique for differentiating between the prostatic adenocarcinoma and BPH were evaluated. Materials & Methods: Using a descriptive study 15 prostatic adenocarcinoma samples (without spot to histologic grade) and 15 BPH samples were selected and stained with AgNOR method. Specimens were taken from paraffin block in Pathology laboratory archive. Results: The average AgNOR points in BPH and prostatic adenocarcinoma were1.39 and 2.48 per cell, respectively. In BPH there was one or two points of AgNOR with specific margin but in prostatic adenocarcinoma numerous arranged AgNOR points were seen. While the number of cells in BPH with three or more AgNOR points were 4.7, in prostatic adenocarcinoma it was 41.47. Conclusion: AgNOR is a useful method to differentiate between benign prostatic hyperplasia and prostatic adenocarcinoma.

Item Type: Article
Subjects: Medicine
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 10 May 2017 15:00
Last Modified: 03 Jun 2017 13:46
URI: http://eprints.kaums.ac.ir/id/eprint/2016

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