Foroozanfard, F. and Pejman Manesh, M. and Mahdian, Mehrdad and Moosavi, G.A. (2010) Comparing the combined effect of letrozole and clomiphene regimen plus gonadotropins on pregnancy rate in clomiphene resistant-polycystic ovarian syndrome. Feyz Journal of Kashan University of Medical Sciences, 14.
Full text not available from this repository.Abstract
Background: Although clomiphene citrate is the first line in ovulation induction in anovulatory infertile women, but some of polycystic ovarian syndrome (PCOS) patients are clomiphene-resistant. This study was carried out to compare the combined effect of letrozole and clomiphene with gonadotropins on pregnancy rate in clomiphene-resistant PCOS patients. Materials and Methods: This clinical trial study was carried out on 120 clomiphene-resistant PCOS patients. The patients were randomly divided into two groups: group 1 received clomiphene (100 mg/day) and group 2 received letrozole (5 mg/day) on the 3–7 th days of menstrual cycle. Both groups received (150 IU/im) HMG on the 5–8 th days of menstrual cycle. On 10-11 th days of menstrual cycle, transvaginal sonography was performed to determine endometrial thickness, dominant follicle number and increase HMG dose, if required. HCG at a dose of 5000 IU was administered when at least one mature follicle was observed. β-HCG level was evaluated 2 weeks after HCG administration. The two groups were compared for mature follicles numbers, endometrial thickness, gonadotropin consumption and pregnancy rate. Chi–square, Kolomogrov–Smirnov, t-test, Levene, Mann-Whitney tests were used to analyze data. Results: Although the pregnancy rate in letrozole group was higher than in the clomiphene one, the difference was not significant (36.7% vs 33.3%, P=0.702). The mean endometrial thickness in letrozole and clomiphene group was 7.47 mm and 7.49 mm, respectively (P=0.685). In letrozole and clomiphene group the mean of dominant follicles numbers was 2.18 and 2.83, respectively (P=0.087) while the gonadotropin level mean in both groups was 6.78 (p=0.941). Conclusion: In clomiphene resistant PCOS patients, similar to clomiphene, letrozole in combined regimens with gonadotropin can be effective for the induction of ovulation.
| Item Type: | Article |
|---|---|
| Subjects: | Midwifery |
| Divisions: | Feyz journal |
| Depositing User: | ART . editor |
| Date Deposited: | 10 May 2017 14:23 |
| Last Modified: | 28 May 2017 12:25 |
| URI: | http://eprints.kaums.ac.ir/id/eprint/1990 |
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