Rectal diclofenac versus rectal paracetamol: Comparison of antipyretic effectiveness in children

Sharif, M.R. and Haji Rezaei, M. and Aalinezhad, M. and Sarami, G. and Rangraz, M. (2016) Rectal diclofenac versus rectal paracetamol: Comparison of antipyretic effectiveness in children. Iranian Red Crescent Medical Journal, 18 (1).

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Background: Fever is the most common complaint in pediatric medicine and its treatment is recommended in some situations. Paracetamol is the most common antipyretic drug, which has serious side effects such as toxicity along with its positive effects. Diclofenac is one of the strongest non-steroidal anti-inflammatory (NSAID) drugs, which has received little attention as an antipyretic drug. Objectives: This study was designed to compare the antipyretic effectiveness of the rectal form of Paracetamol and Diclofenac. Patients and Methods: This double-blind controlled clinical trial was conducted on 80 children aged six months to six years old. One group was treated with rectal Paracetamol suppositories at 15 mg/kg dose and the other group received Diclofenac at 1 mg/kg by rectal administration (n=40). Rectal temperature was measured before and one hour after the intervention. Temperature changes in the two groups were compared. Results: The average rectal temperature in the Paracetamol group was 39.6 ± 1.13°C, and 39.82 ± 1.07°C in the Diclofenac group (P = 0.37). The average rectal temperature, one hour after the intervention, in the Paracetamol and the Diclofenac group was 38.39 ± 0.89°C and 38.95 ± 1.09°C, respectively (P = 0.02). Average temperature changes were 0.65 ± 0.17°C in the Paracetamol group and 1.73 ± 0.69°C in the Diclofenac group (P < 0.001). Conclusions: In the first one hour, Diclofenac suppository is able to control the fever more efficient than Paracetamol suppositories. © 2016, Iranian Red Crescent Medical Journal.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: diclofenac; paracetamol, analgesic activity; antipyretic activity; Article; body temperature measurement; child; clinical trial; controlled study; double blind procedure; drug efficacy; female; fever; human; infant; major clinical study; male; preschool child; questionnaire; rectum temperature; suppository; thermometer
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Pediatrics
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 22:06
Last Modified: 08 Mar 2017 22:06

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