Toxoplasmosis-associated abortion and stillbirth in Tehran, Iran

Ghasemi, F.S. and Rasti, S. and Piroozmand, A. and Bandehpour, M. and Kazemi, B. and Moosavi, G.A. and Abdoli, A. (2016) Toxoplasmosis-associated abortion and stillbirth in Tehran, Iran. Journal of Maternal-Fetal and Neonatal Medicine, 29 (2). pp. 248-251.

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Objectives: This study was aimed to evaluate the role of toxoplasmosis in etiology of abortion and stillbirth based on molecular and serological techniques.Material and methods: A total of 110 pregnant women with abortion and stillbirth were enrolled as the case group, and 110 pregnant women with normal delivery were enrolled as the control group. Serological and molecular detections of Toxoplasma gondii were assessed by ELISA and PCR methods.Results: The seroprevalence of IgG was 25.5 in the case group (26.8 in abortion and 21.4 in stillbirth) and 26.4 in the control group. IgM seropositivity was detected in 2.7 of the case group (3.6 in abortion and 0 in stillbirth) and 0.9 of the control group (p = 0.37). Toxoplasma gondii DNA was detected in 6.4 of the case group (7.3 in abortion and 3.6 in stillbirth) and 1.8 of the control group by PCR (p = 0.17). The major risk factor of congenital toxoplasmosis was the history of eating undercooked meat (p = 0.06).Conclusion: Results of this study revealed that the rate of PCR positive in women with abortion and stillbirth was 3.7 times higher than that in normal delivery, but the difference was not statistically significant. These findings suggest that toxoplasmosis can be involved in etiology of abortion and stillbirth. © 2015 Informa UK Ltd.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: DNA; immunoglobulin G; immunoglobulin M, adult; Article; congenital toxoplasmosis; controlled study; delivery; DNA determination; enzyme linked immunosorbent assay; female; human; Iran; major clinical study; nucleotide sequence; polymerase chain reaction; pregnancy termination; pregnant woman; prevalence; priority journal; risk factor; serology; seroprevalence; Toxoplasma gondii; toxoplasmosis associated abortion and stillbirth; case control study; complication; congenital toxoplasmosis; parasitology; pregnancy; spontaneous abortion; stillbirth, Abortion, Spontaneous; Adult; Case-Control Studies; Female; Humans; Iran; Pregnancy; Stillbirth; Toxoplasmosis, Congenital
Subjects: Parasitology
Divisions: Faculty of Medicine > Basic Sciences > Department of Parasitological & Mycology
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 22:05
Last Modified: 08 Mar 2017 22:05

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