Omega-3 fatty acid supplementation affects pregnancy outcomes in gestational diabetes: A randomized, double-blind, placebo-controlled trial

Jamilian, M. and Samimi, M. and Kolahdooz, F. and Khalaji, F. and Razavi, M. and Asemi, Z. (2016) Omega-3 fatty acid supplementation affects pregnancy outcomes in gestational diabetes: A randomized, double-blind, placebo-controlled trial. Journal of Maternal-Fetal and Neonatal Medicine, 29 (4). pp. 669-675.

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Objective: This study was designed to assess the effects of omega-3 fatty acid supplementation on inflammatory factors, biomarkers of oxidative stress, and pregnancy outcomes among pregnant women with gestational diabetes (GDM).Methods: This randomized, double-blind, placebo-controlled clinical trial was performed among 56 women with GDM. Subjects were randomly selected to receive either 1000 mg omega-3 fatty acid supplements (containing 180 mg eicosapentaenoic acid and 120 mg docosahexanoic acid) (n = 27) or a placebo (n = 27) for 6 weeks. Fasting blood samples were taken at study baseline and after 6 weeks of intervention to quantify biochemical variables. Newborns weight, height, head circumference, Apgar score, and hyperbilirubinemia were determined.Results: At the end of the 6 weeks, taking omega-3 fatty acid significantly decreased serum high-sensitivity C-reactive protein (hs-CRP) (change from baseline: -245.1 ± 1570.5 versus + 913.9 ± 2329.4 ng/mL, p = 0.03) and plasma malondialdehyde (MDA) concentrations (-0.4 ± 1.3 versus + 0.6±2.3, p = 0.04) compared with the placebo. Supplementation with omega-3 had a low incidence of hyperbilirubinemiain newborns (7.7 versus 33.3, p = 0.02) and decreased newborns hospitalization rate (7.7 versus 33.3, p = 0.02).Conclusions: Taken together, omega-3 fatty acid supplementation in GDM women had beneficial effects on maternal serum hs-CRP, plasma MDA levels, incidence of newborns hyperbilirubinemia, and hospitalization. © 2015 Informa UK Ltd.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: C reactive protein; docosahexaenoic acid; icosapentaenoic acid; malonaldehyde; omega 3 fatty acid; C reactive protein; malonaldehyde; omega 3 fatty acid, adult; Apgar score; Article; birth weight; caloric intake; carbohydrate intake; controlled study; drug efficacy; drug response; fat intake; female; head circumference; human; hyperbilirubinemia; incidence; major clinical study; neonatal hyperbilirubinemia; oxidative stress; pregnancy diabetes mellitus; pregnancy outcome; pregnant woman; priority journal; protein blood level; protein intake; randomized controlled trial; blood; Diabetes, Gestational; dietary supplement; double blind procedure; hospitalization; Hyperbilirubinemia, Neonatal; Iran; newborn; pregnancy; statistics and numerical data, Adult; C-Reactive Protein; Diabetes, Gestational; Dietary Supplements; Double-Blind Method; Fatty Acids, Omega-3; Female; Hospitalization; Humans; Hyperbilirubinemia, Neonatal; Infant, Newborn; Iran; Malondialdehyde; Pregnancy
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 06 Mar 2017 16:52
Last Modified: 06 Mar 2017 16:52

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