Effect of multi mineral-vitamin D supplementation on metabolic profiles, hs-CRP and oxidative stress in pregnant women at risk for pre-eclampsia: a randomized controlled clinical trial

Asemi, Z. and Samimi, M. and Tabassi, Z. and Shakeri, H. and Sabihi, S.S. and Borojerdi-Alavi, M. and Jafari, Z. and Motaharian, F. and Heidarzadeh, Z. and Ghandi, Y. (2013) Effect of multi mineral-vitamin D supplementation on metabolic profiles, hs-CRP and oxidative stress in pregnant women at risk for pre-eclampsia: a randomized controlled clinical trial. Feyz Journal of Kashan University of Medical Sciences, 16.

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Official URL: http://feyz.kaums.ac.ir/article-1-1859-en.html
DOI: UNSPECIFIED

Abstract

Background: The purpose of this study was to determine the favorable effects of multi mineral-vitamin D supplementation on metabolic profiles, serum hs-CRP and biomarkers of oxidative stress among Iranian pregnant women at risk for pre-eclampsia. Materials and Methods: This randomized single-blind controlled clinical trial was conducted among 48 pregnant women, primigravida, at risk for pre-eclampsia aged 18-40 years at their third trimester. Pregnant women were randomly assigned to receive either the multi mineral-vitamin D supplements (n=24) or the placebo (n=24) for 9 weeks. Fasting blood samples were taken at baseline and after 9 weeks of intervention to measure metabolic profiles, hs-CRP and oxidative stress parameters.Results: Consumption of multi mineral-vitamin D supplements as compared to the placebo resulted in a significant decrease in FPG (-11.7 vs. -2 mg/dL, P=0.01), serum insulin levels (-0.96 vs. 2.65 µIU/ml, P=0.04) and a marginally significant decrease in HOMA-IR (-0.34 vs.0.6, P=0.06). Also, multi mineral-vitamin D supplementation resulted in a significant decrease in serum hs-CRP levels as compared to the placebo (-1411.7 vs. 1503 ng/ml, P=0.01). Moreover, the mean changes for plasma TAC (151.94 vs. -19.69 mmol/l, P=0.002) and total GSH levels (205.82 vs. -32.3 µmol/l, P=0.02) were significantly different between the two groups.Conclusion: In conclusion, consumption of multi mineral-vitamin D supplements for 9 weeks during pregnancy among pregnant women at risk for pre-eclampsia resulted in a significant decrease in FPG, serum insulin, hs-CRP and increased levels of plasma TAC and total GSH as compared to the placebo group.

Item Type: Article
Subjects: Nutrition
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 09 May 2017 13:18
Last Modified: 23 May 2017 13:25
URI: http://eprints.kaums.ac.ir/id/eprint/1815

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