A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids and Vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes

Taghizadeh, M. and Jamilian, M. and Mazloomi, M. and Sanami, M. and Asemi, Z. (2016) A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids and Vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes. Journal of Clinical Lipidology, 10 (2). pp. 386-393.

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Abstract

Background Limited data are available that evaluated the effects of combined omega-3 fatty acids and vitamin E supplementation on glucose homeostasis parameters and lipid concentrations in gestational diabetes (GDM). Objectives The present study was designed to determine the effects of omega-3 fatty acids and vitamin E co-supplementation on glucose homeostasis parameters and lipid concentrations among women with GDM who were not on oral hypoglycemic agents. Methods This prospective randomized, double-blind, placebo-controlled clinical trial was carried out among 60 patients with GDM. Patients were randomly allocated to take either 1000-mg omega-3 fatty acids from flaxseed oil plus 400-IU vitamin E supplements (n = 30) or placebo (n = 30) for 6 weeks. Fasting blood samples were obtained from at the beginning of the study and after 6-week intervention to quantify related variables. Results After 6 weeks of intervention, changes in fasting plasma glucose (-11.8 ± 11.0 vs +1.5 ± 11.9 mg/dL, P <.001), serum insulin concentrations (-1.8 ± 6.9 vs +5.8 ± 12.1 μIU/mL, P =.004), homeostasis model of assessment-estimated insulin resistance (-0.8 ± 1.6 vs +1.4 ± 2.8, P =.001), homeostasis model of assessment-estimated beta cell function (-0.2 ± 27.7 vs +22.8 ± 48.2, P =.02), and quantitative insulin sensitivity check index (+0.01 ± 0.02 vs -0.01 ± 0.02, P =.01) in the omega-3 fatty acids plus vitamin E group were significantly different from the changes in these indicators in the placebo group. Changes in serum triglycerides (+10.8 ± 41.5 vs +34.2 ± 35.5 mg/dL, P =.02), VLDL-cholesterol (+2.1 ± 8.3 vs +6.8 ± 7.1 mg/dL, P =.02), low-density lipoprotein (LDL)-cholesterol (+11.6 ± 18.8 vs +1.7 ± 15.9 mg/dL, P =.03) and HDL-cholesterol concentrations (+1.9 ± 8.7 vs -2.4 ± 7.7 mg/dL, P =.04) were significantly different between the supplemented women and placebo group. However, after controlling for baseline total cholesterol levels, maternal age, and BMI at baseline, the changes in serum LDL-cholesterol concentrations were not significantly different between the 2 groups. We did not find any significant effect of joint omega-3 fatty acids and vitamin E supplementation on total cholesterol concentrations. Conclusions Overall, we demonstrated that omega-3 fatty acids and vitamin E co-supplementation in GDM women had beneficial effects on glucose homeostasis parameters, serum triglycerides, VLDL-cholesterol, and HDL-cholesterol concentrations, but it did not influence total-cholesterol and LDL-cholesterol levels. © 2016 National Lipid Association.

Item Type: Article
Additional Information: cited By 1
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 06 Mar 2017 16:47
Last Modified: 06 Mar 2017 16:47
URI: http://eprints.kaums.ac.ir/id/eprint/178

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