Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

Razavi, M. and Jamilian, M. and Fakhrieh-Kashan, Z. and Heidar, Z. and Mohseni, M. and Ghandi, Y. and Bagherian, T. and Asemi, Z. (2015) Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome. Hormone and Metabolic Research, 48 (3). pp. 185-190.

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Abstract

Selenium supplementation could be effective on reproductive outcomes, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS). The aim of the study was to determine the effects of selenium supplementation on reproductive outcomes, biomarkers of inflammation, and oxidative stress in PCOS patients. The present randomized double-blind, placebo-controlled trial was conducted on 64 women aged 18-40 years old with PCOS at the clinic affiliated to Ardabil University of Medical Sciences, Ardabil, Iran. The participants were randomly assigned to 2 groups receiving either 200 μg selenium daily (n=32) or placebo (n=32) for 8 weeks. Hormonal profiles, biomarkers of inflammation, and oxidative stress were measured and compared both before and after the treatment. After 8 weeks of intervention, pregnancy rate in the selenium group was higher than in the placebo group: 18.8 (6/32) vs. 3.1 (1/32), p=0.04. In addition, alopecia (40.6 vs. 9.4, p=0.004) and acne (46.9 vs. 12.5 , p=0.003) decreased following the consumption of selenium supplements compared with placebo. Additionally, patients who received selenium supplements had significantly decreased serum dehydroepiandrosterone (DHEA) levels (p=0.02), hirsutism (modified Ferriman-Gallwey scores) (p<0.001), serum high sensitivity C-reactive protein (hs-CRP) (p=0.02), and plasma malondialdehyde (MDA) levels (p=0.01) compared with placebo. We did not observe any significant effects of taking selenium supplements on other hormonal profiles, nitric oxide (NO), and other biomarkers of oxidative stress. Taken together, selenium supplementation for 8 weeks among PCOS women had beneficial effects on reproductive outcomes, DHEA, hs-CRP, and MDA levels. Supporting Information for this article is available online at http://www.thieme-connect.de/products. © Georg Thieme Verlag KG Stuttgart. New York.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: biological marker; C reactive protein; malonaldehyde; prasterone; selenium, acne; adult; alopecia; Article; controlled study; dietary intake; disease marker; double blind procedure; female; hirsutism; human; inflammation; intervention study; major clinical study; ovary polycystic disease; oxidative stress; pregnancy rate; priority journal; protein blood level; randomized controlled trial; reproduction; treatment outcome
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 22:16
Last Modified: 08 Mar 2017 22:16
URI: http://eprints.kaums.ac.ir/id/eprint/177

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