Vitamin D and evening primrose oil administration improve glycemia and lipid profiles in women with gestational diabetes

Jamilian, M. and Karamali, M. and Taghizadeh, M. and Sharifi, N. and Jafari, Z. and Memarzadeh, M.R. and Mahlouji, M. and Asemi, Z. (2016) Vitamin D and evening primrose oil administration improve glycemia and lipid profiles in women with gestational diabetes. Lipids, 51 (3). pp. 349-356.

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Abstract

Limited data are available assessing the effects of vitamin D and evening primrose oil (EPO) administration on markers of insulin resistance and lipid concentrations in gestational diabetes mellitus (GDM). This study was designed to evaluate the effects of vitamin D and EPO administration on insulin resistance and lipid concentrations among women with GDM. In this prospective randomized, double-blind, placebo-controlled clinical trial, 60 participants with GDM were divided into 2 groups of either 1000 IU vitamin D3 and 1000 mg EPO or placebo for 6 weeks. At the beginning and end of the study, fasting blood samples were obtained from the participants to measure related variables. After 6 weeks of intervention, changes in fasting plasma glucose (-3.6 ± 7.5 vs. +1.5 ± 11.4 mg/dL, P = 0.04), serum insulin concentrations (-2.0 ± 5.3 vs. +4.6 ± 10.7 μIU/mL, P = 0.004), homeostasis model of assessment (HOMA) insulin resistance (-0.5 ± 1.1 vs. +1.1 ± 2.5, P = 0.003), HOMA-B cell function (-7.7 ± 23.3 vs. +17.4 ± 42.9, P = 0.007) and the quantitative insulin sensitivity check index (+0.01 ± 0.02 vs. -0.01 ± 0.02, P = 0.007) in the vitamin D plus EPO group were significantly different from the placebo group. In addition, compared with the placebo, vitamin D and EPO supplementation resulted in significant reductions in serum TAG (-20.0 ± 54.3 vs. +34.3 ± 38.2 mg/dL, P < 0.001), VLDL (-4.0 ± 10.9 vs. +6.9 ± 7.6 mg/dL, P < 0.001), TC (-22.1 ± 32.6 vs. +5.3 ± 20.1 mg/dL, P < 0.001), LDL concentrations (-18.0 ± 25.5 vs. +1.8 ± 15.7 mg/dL, P = 0.001) and TC/HDL (-0.3 ± 0.4 vs. +0.3 ± 0.5 mg/dL, P < 0.001). We did not observe any significant effect of vitamin D and EPO supplementation on serum HDL concentrations. © 2016 AOCS.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: carbohydrate; cholesterol; colecalciferol; ferrous sulfate; folic acid; high density lipoprotein; insulin; lipid; low density lipoprotein; manganese; monounsaturated fatty acid; placebo; polyunsaturated fatty acid; primrose oil; saturated fatty acid; triacylglycerol; very low density lipoprotein; zinc, adult; Article; blood sampling; caloric intake; controlled study; diabetic patient; diet restriction; dietary fiber; double blind procedure; female; glucose blood level; human; insulin blood level; insulin resistance; major clinical study; pregnancy diabetes mellitus; prospective study; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; treatment duration; triacylglycerol blood level; vitamin supplementation
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 22:13
Last Modified: 11 Mar 2017 13:51
URI: http://eprints.kaums.ac.ir/id/eprint/173

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