Identification of serological groups A, B, C, W135, Y, X Neisseria meningitidis carriers by multiplex PCR in the nasopharynx of students in Kashan during 2011-2012

Valipour, M. and Piroozmand, A. and Khorshidi, A. and Akbari, H. and Mirzaee, H. (2013) Identification of serological groups A, B, C, W135, Y, X Neisseria meningitidis carriers by multiplex PCR in the nasopharynx of students in Kashan during 2011-2012. Feyz Journal of Kashan University of Medical Sciences, 17.

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Official URL: http://feyz.kaums.ac.ir/article-1-1911-en.html
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Abstract

Background: Neisseria meningitidis (N. meningitidis) is a pathogen which colonizes in the nasopharynx without any clinical manifestations. Among the 13 different serological groups, only the serogroups A, B, C, W135, Y, X play a major role in disease development. This study aimed to determine N. meningitidis cases carrying these serological groups using the multiplex PCR method in the nasopharynx of students in Kashan schools . Materials and Methods: This cross-sectional study was conducted on 1289 students in Kashan during 2011-2012. Samples were collected from the students' nasopharynx using a sterile swab and cultured on a selective medium . Strains were identified through biochemical tests. Then the serological groups were determined using the multiplex PCR method. Results: One-hundred and fifteen (8.9%) out of 1289 students were N.meningitidis carriers 75 (65.2%) male and 40 (34.8%) female. There was a significant difference between gender and the rate of carriers (P=0.032). The highest rate of carriers (12.3%) was in the 15 to 19 year age group. There was a significant relationship between the rate of carriers and increase in the number of family members (P<0.001). In this study, only the serological groups B (8 cases) and C (107 cases) were detected. Conclusion: Since the serological group C is involved in the outbreak and there is no vaccine currently available for the serological group B to prevent the infection, detection of these serological groups can be important.

Item Type: Article
Subjects: Immunology and Microbiology
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 08 May 2017 15:03
Last Modified: 23 May 2017 17:17
URI: http://eprints.kaums.ac.ir/id/eprint/1713

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