The effect of concomitant administration of furosemide and salbutamol on spirometry parameters in persistent asthma

Saba, M.A. and Taghadosi, M. and Kasaee, S.S. and Akbari, H. (2013) The effect of concomitant administration of furosemide and salbutamol on spirometry parameters in persistent asthma. Feyz Journal of Kashan University of Medical Sciences, 17.

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Official URL: http://feyz.kaums.ac.ir/article-1-1899-en.html
DOI: UNSPECIFIED

Abstract

Background: Considering the effectiveness of nebulized furosemide in asthma crisis that were non-responsive to the inhalational β-agonists , this study aimed to examine the effect of concomitant administration of furosemide (10 mg) and nebulized salbutamol (2.5 mg) on spirometry parameters in persistent asthma. Materials and Methods: In this clinical trial, 53 patients (age, 18-75 years) with a 6-months history of persistent asthma were randomly allocated to two groups, the salbutamol (n=27) and salbutamol + furosemide (n=26) groups. Participants in each group were classified into the mild, moderate and severe persistent asthma on the basis of FEV1 . Participants were administered salbutamol or salbutamol + furosemide, and then the spirometry parameters were recorded 15 minutes after the completion of nebulization treatment . Before and after the treatment, mean and standard deviation of the spirometry parameters and their changes were calculated . Results: Results showed no significant difference regarding the mean percentage change for FEV1 in the salbutamol (27.5) and salbutamol + furosemide groups (25.83) after the treatment (P=0.72). Moreover, no significant difference was seen between the two groups regarding the mean percentage changes in other parameters after the treatment (FVC, FEV1, PEF, MMEF, FEV1/FVC, P>0.25). Conclusion: Concomitant administration of furosemide and salbutamol has no advantage over salbutamol in normalizing the spirometry parameters of persistent asthma.

Item Type: Article
Subjects: Pharmacology, Toxicology and Pharmaceutics
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 08 May 2017 14:56
Last Modified: 23 May 2017 17:11
URI: http://eprints.kaums.ac.ir/id/eprint/1706

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