Pouyanmanesh, F. and Nabiuni, M. and Nasri, S. and Nazari, Z. and Karimzadeh, L. (2013) The effect of honey bee venom on levels of lipids and anti-mullerian hormone in a rat with polycystic ovarian syndrome. Feyz Journal of Kashan University of Medical Sciences, 17.
Full text not available from this repository.Abstract
Background: Polycystic ovarian syndrome (PCOS) is an inflammatory disease. Honey bee venom (HBV) contains a variety of enzymes and biologically active amines that its analgesic and anti-inflammatory effects have been established on PCOS. This study aimed to examine the effect of HBV on changes in anti-mullerian hormone (AMH), triglyceride and LDL levels in rats with PCOS. Materials and Methods: This experimental study was conducted on 63 female Wistar rats. PCOS was induced by a single-stage subcutaneous injection of Estradiol Valerate (2 mg⁄100grBW). After 60 days of injection, HBV dissolved in PBS (0.2 mg/kg) was injected intraperitoneally for ten days. Then the rats were sacrificed and the ovarian tissues in the control, PCOS and HBV-treated PCOS groups were collected for histological study. Finally, the blood serum was isolated to measure the changes in lipid and AMH levels using ELISA method. Results: Histological studies showed a significant reduction in corpus luteum (CL) diameter in PCOS group compared with the control group an increase in CL in the HBV-treated group compared with the PCOS group. Blood triglycerides and LDL levels in PCOS group were increased compared with the control group, while it was decreased in the HBV-treated group. Moreover, AMH increased in the PCOS group compared with the control one, but it was decreased in the HBV group. Conclusion: HBV has a beneficial effect on PCOS probably through the expression of AMH factor and the reduction of triglycerides and LDL levels.
| Item Type: | Article |
|---|---|
| Subjects: | Pharmacology, Toxicology and Pharmaceutics |
| Divisions: | Feyz journal |
| Depositing User: | ART . editor |
| Date Deposited: | 08 May 2017 14:41 |
| Last Modified: | 30 May 2017 13:32 |
| URI: | http://eprints.kaums.ac.ir/id/eprint/1694 |
Actions (login required)
 |
View Item |
