Role of capsaicin receptors in periaqueductal gray on pain modulation in diabetic rats

Shirafkan, T. and Sarihi, A. and Komaki, A.R. (2013) Role of capsaicin receptors in periaqueductal gray on pain modulation in diabetic rats. Feyz Journal of Kashan University of Medical Sciences, 17.

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Official URL: http://feyz.kaums.ac.ir/article-1-2018-en.html
DOI: UNSPECIFIED

Abstract

Background: Numerous studies have shown the presence of capsaicin (CAP) receptors in periaqueductal gray (PAG) area. The aim of this study was to examine the role of CAP receptors in PAG on pain modulation in diabetic neuropathic (NP) rats. Materials and Methods: This experimental study was carried out on 24 male rats in 4 groups (n=6): normal - saline normal - capsaicine NP - saline and NP - capsaicine. To investigate the effect of intra-PAG injection of capsaicin (10 nmol/ul) or saline on pain modulation, tail flick (TF), hot plate and Von frey tests were used. To induce NP, a single dose of streptozotocin (55 mg/kg, i.p) was injected. Results: In normal rats, 5 and 15 min after the injection into PAG, CAP showed an analgesic effect in TF test (P

Item Type: Article
Subjects: Neuroscience
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 08 May 2017 14:24
Last Modified: 06 Jun 2017 18:11
URI: http://eprints.kaums.ac.ir/id/eprint/1683

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