Investigating the cytotoxic effects of ethanolic extract of Ferula assa-foetida resin on HepG2 cell line

Sadooghi, S.D. and Nezhad Shahrokh Abadi, Kh. and Zafar Balanzhad, S. and Baharara, J. (2013) Investigating the cytotoxic effects of ethanolic extract of Ferula assa-foetida resin on HepG2 cell line. Feyz Journal of Kashan University of Medical Sciences, 17.

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Official URL: http://feyz.kaums.ac.ir/article-1-1997-en.html
DOI: UNSPECIFIED

Abstract

Background: Resin of Ferula assa-foetida has medicinal properties and various studies have shown its antioxidant and anticancer effects. The aim of this study was to evaluate the cytotoxic effect of ethanolic extract of Ferula assa-foetida resin on HepG2 cell line. Materials and Methods: In this experimental study, the effect of ethanolic extract of Ferula assa-foetida resin on HepG2 cell line and L929 normal cell line was investigated. The RPMI medium contains L- glutamine, penicillin , streptomycin and 10 FBS. Morphological changes were evaluated using an inverted microscope 24 , 48, 72 , 96 hours after adding the resin of Ferula assa-foetida extract (10, 50 , 100, 200 μg /ml) . Cell viability was determined using MTT assay . Results: Ethanolic extract of Ferula assa-foetida resin ( 50, 100 , 200 μg /ml ) were induced morphological changes in HepG2 cells after 24 hours which were prominent after 48 , 72 and 96 hours. At concentrations of 100 and 200 μg /ml, morphological changes were observed in normal cells. Results of MTT assay showed a significant decrease in viability of HepG2 cells at concentrations of 50, 100, 200 μg /ml . Concentrations of 100 and 200 μg /ml significantly reduced the viability of L929 cell (P

Item Type: Article
Subjects: Medicine
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 08 May 2017 14:19
Last Modified: 24 May 2017 02:54
URI: http://eprints.kaums.ac.ir/id/eprint/1681

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