Involvement of dorsal hippocampal beta-1 noradrenergic receptors in memory retrieval of rats

Fathinia, K. and Khajehpour, L. and Moazedi, A.A. and Bemani-Lirgeshasi, S. (2014) Involvement of dorsal hippocampal beta-1 noradrenergic receptors in memory retrieval of rats. Feyz Journal of Kashan University of Medical Sciences, 17.

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Background: Central beta-noradrenergic system plays an important role in the learning and memory processes. Dorsal hippocampus also has an overlapped distribution of beta-noradrenergic receptors. The aim of this study was to evaluate the possible role of the dorsal hippocampal beta-1 noradrenergic receptors in memory retrieval using a passive avoidance learning task. Materials and Methods: This experimental study was performed on adult male Wistar rats (weight, 230±20gr). After anaesthetizing, the rats were cannulated into dorsal hippocampus using the stereotaxic surgery. After one week, passive avoidance memory was studied in two phases: training and testing with a 24h interval. The step-through latency to enter dark compartment and the time spent in this compartment was recorded for the evaluation of memory. All animals received drugs or saline, as intra- dorsal hippocampal microinjection, 30 min before testing. Results: Pre-testing administration of dobutamine (1 μg/rat), a beta-1 noradrenergic receptor agonist, potentiated passive avoidance memory retrieval, while pre-testing injection of betaxolol (0.5μg/rat), a beta-1 noradrenergic receptor antagonist, inhibited passive avoidance memory retrieval. Also, the injection of ineffective and low doses of betaxolol (0.125 and 0.25 μg/rat) inhibited the effect of dobutamine on the memory retrieval. Conclusion: It seems that beta-1 noradrenergic receptors of the dorsal hippocampus may mediate memory retrieval in a passive avoidance learning model.

Item Type: Article
Subjects: Neuroscience
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 08 May 2017 12:57
Last Modified: 24 May 2017 18:46

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