Celebrex versus magnesium sulfate to prevent premature labor

Salarieh, N. and Tabasi, Z. and Foroozanfard, F. and Mahdian, Mehrdad and Moosavi, G.A. (2014) Celebrex versus magnesium sulfate to prevent premature labor. Feyz Journal of Kashan University of Medical Sciences, 18.

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Official URL: http://feyz.kaums.ac.ir/article-1-2178-en.html
DOI: UNSPECIFIED

Abstract

Background: Preterm labor is the leading cause of newborn deaths and a major public health challenge. The aim of this study was to compare the effect of celebrex and magnesium sulfate in the prevention of preterm labor. Materials and Methods: In this double-blind clinical trial, 100 patients with preterm uterine contractions were randomly allocated into two groups: one group received oral celebrex 100 mg twice daily and another group received magnesium sulfate intravenously for up to 48 hours. A 48-hour delay in delivery and the drug complications were evaluated. Results: There was no significant difference between the two groups regarding maternal age, parity and gestational age. A 48-hour delay in delivery was observed for 42 patients in each group (86) and was the same for both groups. Delivery before 48 hours was also observed for 8 patients (14) in each group and was the same for both groups. Conclusion: The tocolytic efficacy of celebrex is equal to that of magnesium sulfate, the most commonly used tocolytic agent. So, for its ease of use celebrex is recommended for the prevention of preterm labor in pregnant women with preterm uterine contractions.

Item Type: Article
Subjects: Midwifery
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 08 May 2017 12:33
Last Modified: 28 May 2017 12:27
URI: http://eprints.kaums.ac.ir/id/eprint/1643

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