The association of high risk human papillomaviruses in patients with cervical cancer: An evidence based study on patients with squamous cell dysplasia or carcinoma for evaluation of 23 human papilloma virus genotypes

Piroozmand, A. and Mostafavi-Zadeh, S.M. and Madani, A. and Soleimani, R. and Nedaeinia, R. and Niakan, M. and Avan, A. and Manian, M. and Moradi, M. and Eftekhar, Z. (2016) The association of high risk human papillomaviruses in patients with cervical cancer: An evidence based study on patients with squamous cell dysplasia or carcinoma for evaluation of 23 human papilloma virus genotypes. Jundishapur Journal of Microbiology, 9 (4).

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Abstract

Background: Cervical cancer is one of the leading causes of cancer-related death in females. Human papilloma virus (HPV) is the major risk factor of cervical cancer. Objectives: The aim of the current study was to explore the frequency and role of 23 different HPVs in patients with cervical cancer. Materials and Methods: Overall, 117 formalin-fix and paraffin-embedded (FFPE) tissues from cervical cancer patients with squamous cell carcinoma (SCC) or dysplasia were collected from Mirza-Kochakkhan-Jangali hospital, Tehran, Iran during year 2013, to investigate the presence of HPV- HPV- 67, 68, 6, 11, 13, 16, 17, 30, 69, 39, 40, 42, 64, 66 and 51 to 59 genotypes. Results: The Pap smear report illustrated the presence of malignancy in 71 cases, while 11 cases had no evidence of malignancy. Among the patients, 26 cases had sexually transmitted disease with relative frequency of 0.58. Infection with papilloma virus was observed in 83.6 of SCC patients and 45 of the dysplasia group. The most prevalent HPV genotypes were 18 with 31.62 and 16 with 27.35 of cases. Moreover the relative frequencies of HPV-33, -6, -58, -52, -35 and -51, genotypes were 15.38, 7.69, 5.98, 5.12 and 3.41, respectively. Among the different genotypes of HPV, 31 had the lowest and 16 had the highest relative frequency. Conclusions: Our findings demonstrate that HPV-16 and -18 have a higher prevalence in our population than 31 and 51. Further investigations are required to evaluate the role of these genotypes in a larger multicenter setting for establishing their values for early detection of patients, which is useful for screening and vaccination programs of cancerous and precancerous lesions of cervical cancer. © 2016, Ahvaz Jundishapur University of Medical Sciences.

Item Type: Article
Additional Information: cited By 0
Subjects: Immunology and Microbiology
Divisions: Faculty of Medicine > Basic Sciences > Department of Microbiology & Immunology
Depositing User: editor . 2
Date Deposited: 05 Mar 2017 20:29
Last Modified: 05 Mar 2017 20:29
URI: http://eprints.kaums.ac.ir/id/eprint/164

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