Molecular screening of Y chromosome microdeletions in AZFc and AZFd regions of the non-obstructive azoospermic patients referred to Alzahra hospital in Tabriz

Akbarzadeh-Khiavi, M. and Rahmani, S.A. and Akbarzadeh-Khiavi, T. and Safary, A. (2014) Molecular screening of Y chromosome microdeletions in AZFc and AZFd regions of the non-obstructive azoospermic patients referred to Alzahra hospital in Tabriz. Feyz Journal of Kashan University of Medical Sciences, 18.

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Official URL: http://feyz.kaums.ac.ir/article-1-2228-en.html
DOI: UNSPECIFIED

Abstract

Background: The Y-chromosome azoospermic factor (AZF) regions consist of genes whose specific roles and functions in spermatogenesis have not been completely clarified. Hence, recognition of the association between AZF microdeletions and male infertility has suggestions for the diagnosis, treatment, and genetic counseling among infertile patients. Materials and Methods: This descriptive-analytical study was performed on 47 infertile men with non-obstructive azoospermic and normal karyotypes referred to infertility center of Alzahra hospital in Tabriz. Molecular AZF screening technique was performed on the genomic DNA from peripheral blood samples. Multiplex PCR and two different sets of sequence-tagged sites (STS) were used to detect the microdeletions in Y-chromosomal AZF regions and the Y specific sequences. Results: Seventeen (36.17) out of 47 infertile men had deletions in the AZFc and AZFd regions (P

Item Type: Article
Subjects: Medicine
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 08 May 2017 12:19
Last Modified: 23 May 2017 15:49
URI: http://eprints.kaums.ac.ir/id/eprint/1631

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