Abbasi, Z. and Fereidoni, M. and Behnam-Rasouli, M. (2014) The effect of intrathecal administration of Genipin on rat paw inflammatory edema in the presence and absence of morphine. Feyz Journal of Kashan University of Medical Sciences, 18.
Full text not available from this repository.Abstract
Background: Uncoupling protein 2 (UCP2) is an intramembranous mitochondrial protein that the knocking down of its gene causes an induction of the pro-inflammatory responses. However, genipin, as a pharmacological inhibitor of UCP2, has anti-inflammatory effects. In this study the effect of genipin on rat paw inflammatory edema induced by formalin in the presence and absence of morphine was investigated. Materials and Methods: In this research, male Wistar rats (200-250g) were assigned to seven groups: Saline(i.p)-Saline(i.t), Saline(i.p)-DMSO(i.t), Saline(i.p)-genipin(i.t), Morphine (10mg/kg,i.p)-DMSO(i.t), Morphine(10mg/kg,i.p)-genipin(i.t), Morphine(1μg/kg,i.p)-DMSO(i.t) and Morphine(1μg/kg,i.p)-genipin(i.t). Inflammation was induced in the rat�s hind paw by the injection of 50 µl of formalin 2.5 and paw volume was measured using plethysmometer method before and after the injection. Results: Results revealed an anti-inflammatory effect for genipin against the formalin-induced paw edema (P
| Item Type: | Article |
|---|---|
| Subjects: | Pharmacology, Toxicology and Pharmaceutics |
| Divisions: | Feyz journal |
| Depositing User: | ART . editor |
| Date Deposited: | 07 May 2017 16:54 |
| Last Modified: | 21 May 2017 14:41 |
| URI: | http://eprints.kaums.ac.ir/id/eprint/1609 |
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