Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial

Jamilian, M. and Foroozanfard, F. and Bahmani, F. and Talaee, R. and Monavari, M. and Asemi, Z. (2016) Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. Biological Trace Element Research, 170 (2). pp. 271-278.

Full text not available from this repository.
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....
DOI: UNSPECIFIED

Abstract

The current study was conducted to evaluate the effects of zinc supplementation on endocrine outcomes, biomarkers of inflammation, and oxidative stress in patients with polycystic ovary syndrome (PCOS). This study was a randomized double-blind, placebo-controlled trial. Forty-eight women (18�40 years) with PCOS diagnosed according to Rotterdam criteria were randomly assigned to receive either 220 mg zinc sulfate (containing 50 mg zinc) (group 1; n = 24) and/or placebo (group 2; n = 24) for 8 weeks. Hormonal profiles, biomarkers of inflammation, and oxidative stress were measured at study baseline and after 8-week intervention. After 8 weeks of intervention, alopecia (41.7 vs. 12.5 , P = 0.02) decreased compared with the placebo. Additionally, patients who received zinc supplements had significantly decreased hirsutism (modified Ferriman-Gallwey scores) (�1.71 ± 0.99 vs. �0.29 ± 0.95, P < 0.001) and plasma malondialdehyde (MDA) levels (�0.09 ± 1.31 vs. +2.34 ± 5.53 μmol/L, P = 0.04) compared with the placebo. A trend toward a significant effect of zinc intake on reducing high-sensitivity C-reactive protein (hs-CRP) levels (P = 0.06) was also observed. We did observe no significant changes of zinc supplementation on hormonal profiles, inflammatory cytokines, and other biomarkers of oxidative stress. In conclusion, using 50 mg/day elemental zinc for 8 weeks among PCOS women had beneficial effects on alopecia, hirsutism, and plasma MDA levels; however, it did not affect hormonal profiles, inflammatory cytokines, and other biomarkers of oxidative stress. © 2015, Springer Science+Business Media New York.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: C reactive protein; hydroxyprogesterone; malonaldehyde; metformin; placebo; zinc sulfate, absence of side effects; adult; alopecia; antioxidant activity; Article; blood level; clinical article; controlled study; double blind procedure; drug effect; female; hirsutism; human; inflammation; mineral supplementation; ovary polycystic disease; oxidative stress; patient compliance; randomized controlled trial; treatment duration
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 06 Mar 2017 16:45
Last Modified: 06 Mar 2017 16:45
URI: http://eprints.kaums.ac.ir/id/eprint/159

Actions (login required)

View Item View Item