Comparing the effects of the aqueous extract of Aloe vera and Na+ Nitroprusside on the contraction of rat isolated thoracic aorta

Khodaei, F. and Mesdaghinia, A. and Hamidi, G.A. and Noureddini, M. (2015) Comparing the effects of the aqueous extract of Aloe vera and Na+ Nitroprusside on the contraction of rat isolated thoracic aorta. Feyz Journal of Kashan University of Medical Sciences, 18.

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Official URL: http://feyz.kaums.ac.ir/article-1-2467-en.html
DOI: UNSPECIFIED

Abstract

Background: Aloe vera is used in traditional medicine to treat hypertension. The purpose of this study was to examine the effect of the aqueous extract of Aloe vera (compared to Na+ nitroprusside) on the contraction of the rat isolated thoracic aorta precontracted with 20 mM potassium chloride. Materials and Methods: In this study, 18 rings isolated from the thoracic aorta of 9 Wistar rats (250-300g) were divided into three groups. On the loaded tissue, a tension less than 2 g was applied which then was precontracted with potassium chloride (20mM) in organ bath containing the carbogen-Krebs solution. Changes in aorta contractility in response to cumulative application of vehicle (group I), extract (group II: 5-50 mg/ml) and Na+ Nitroprusside (group III: 0.0001-10 μM) were measured isometrically.Results: The results showed that although Aloe vera has a decreasing effect on the contraction induced by potassium chloride (20mM), this effect was less than the cumulative effect of Na+ nitroprusside (P

Item Type: Article
Subjects: Medicine
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 07 May 2017 16:13
Last Modified: 29 May 2017 14:26
URI: http://eprints.kaums.ac.ir/id/eprint/1583

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