The effect of aqueous extract of Melissa officinalis on the oxidative stress indices in the midbrain tissue

Malek-Mohammadi, R. and Roghani, M. and Salami, M. (2015) The effect of aqueous extract of Melissa officinalis on the oxidative stress indices in the midbrain tissue. Feyz Journal of Kashan University of Medical Sciences, 19.

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Official URL: http://feyz.kaums.ac.ir/article-1-2516-en.html
DOI: UNSPECIFIED

Abstract

Background: Parkinson disease (PD) is a common neuropathologic disorder. It is resulted from degeneration of the dopaminergic neurons of the substantia nigra pars compacta. It is known that the increased level of oxidative stress leads to the degeneration of dopaminergic neurons. Due to the antioxidant activities of Melissa officinalis, this study aimed to assess the effect of aqueous extract of Melissa officinalis on the oxidative stress indices of the midbrain. Materials and Methods: Forty-eight male Wistar rats (weighing 250-300 g) were assigned to four groups including control (CON), control treated with the extract (CONE), leasioned (L) and leasioned treated with the extract (LE). The neurodegeneration was induced through the injection of 12.5 µg 6-hydroxydopamine (6-OHDA) in the left striatum. The CONE and LE groups were pretreated by 1 mg/kg/day of aqueous extract of Melissa officinalis. The extract treatment was repeated three times with a 24-hour interval and then the neurodegeneration was induced in the animals. Two weeks after the neurodegeneration, the plasma level of malondealdehyde (MDA), nitrite, and superoxide dismutase (SOD) were measured. Results: Results showed a significant increase in the level of MDA in the L group pretreatment with the extract considerably declined the plasma concentration of MDA. Moreover, the SOD activity was profoundly lower in the L compared to the CON group. The extract was ineffective on the SOD activity in the LE group. Conclusion: The oral administration of aqueous extract of Melissa officinalis (100 mg/kg) can diminish some stress oxidative inducers in the midbrain.

Item Type: Article
Subjects: Medicine
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 07 May 2017 15:41
Last Modified: 03 Jun 2017 12:04
URI: http://eprints.kaums.ac.ir/id/eprint/1568

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