The effect of metformin on memory retention of inhibitory avoidance learning in streptozotocin-induced rat model of alzheimer's disease

Esmaeili, M.H. and Mafe-Esmaeili, M. (2015) The effect of metformin on memory retention of inhibitory avoidance learning in streptozotocin-induced rat model of alzheimer's disease. Feyz Journal of Kashan University of Medical Sciences, 19.

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Official URL: http://feyz.kaums.ac.ir/article-1-2515-en.html
DOI: UNSPECIFIED

Abstract

Background: Alzheimer's disease (AD) is closely associated with impaired insulin signaling in brain, suggesting it to be a brain-specific form of diabetes and thus termed as the 'type 3 diabetes'. Metformin is one of the most widely used agent against insulin resistance. The present study aimed to investigate the therapeutic effect of metformin on memory retention in streptozotocin (STZ)-induced model of AD in rats using an inhibitory avoidance learning. Materials and Methods: In this experimental study, 56 male Wistar rats were randomly allocated into 7 groups: control STZ-treated, STZ plus saline or metformin. For the induction of AD, STZ (3 mg/kg) was administered bilaterally into lateral ventricles. All rats were trained in shuttle box for inhibitory avoidance learning. Metformin (50, 100, 200 mg/kg, i.p) or saline were injected immediately after the training. The retention test was performed after two days. Results: The results showed that post-training injection of metformin dose-dependently increased the time spent in the light chamber before entering to the dark chamber in STZ-treated rats. Moreover, metformin dose-dependently improved the memory retention in the rats. Conclusion: Post-training injection of metformin dose-dependently enhanced the memory retention in STZ-induced model of AD.

Item Type: Article
Subjects: Neuroscience
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 07 May 2017 15:40
Last Modified: 27 May 2017 13:06
URI: http://eprints.kaums.ac.ir/id/eprint/1567

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