Effect of hydroalcoholic extract of Melia azedarach L. seeds on serum concentration of sex hormones in polycystic ovary syndrome induced in female wistar rats

Azarnia, M. and Kamyab, S.Z. and Mirabolghasemi, S.GH. and Saeidnia, S. (2015) Effect of hydroalcoholic extract of Melia azedarach L. seeds on serum concentration of sex hormones in polycystic ovary syndrome induced in female wistar rats. Feyz Journal of Kashan University of Medical Sciences, 19.

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Official URL: http://feyz.kaums.ac.ir/article-1-2595-en.html
DOI: UNSPECIFIED

Abstract

Background: Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders among the women. Abnormal ovarian cycle is the result of increased LH and relatively decreased FSH along with overproduction of ovarian androgens. According to the previous studies, Melia azedarach L. seed has anti-steroidogenic properties. Therefore, this study aimed to examine the effect of the hydroalcoholic extract of these seeds on the PCOS induced in female rats. Materials and Methods: In this experimental study, PCOS was induced in 30 adult female Wistar rats using the subcutaneous injection of estradiol valerate. The extract of plant material was made using the percolation method. Rats were divided into PCOS, sham and 3 experimental groups (n=6). Rats in the experimental groups were treated with 25, 50 and 75 mg/kg/ip injections of Melia azedarach L. seed hydro-alcoholic extract for 10 days. The sham group received NaCl 0.9 as the vehicle. Serum concentrations of LH, FSH, testosterone (T) and estradiol (E2) were measured using the ELISA method.Results: Serum concentrations of LH in all experimental groups (P

Item Type: Article
Subjects: Midwifery
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 07 May 2017 15:29
Last Modified: 23 May 2017 14:59
URI: http://eprints.kaums.ac.ir/id/eprint/1558

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