The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial

Razzaghi, R. and Pourbagheri, H. and Momen-Heravi, M. and Bahmani, F. and Shadi, J. and Soleimani, Z. and Asemi, Z. (2016) The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial. Journal of Diabetes and its Complications.

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Abstract

Objective: This study was conducted to evaluate the effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). Methods: This randomized, double-blind, placebo-controlled trial was performed among 60 patients with grade 3 DFU according to "Wagner-Meggitt's" criteria. Participants were randomly divided into two groups (each 30 participants) and received either 50,000. IU vitamin D supplements every 2. weeks for 12. weeks (group A) or placebo (group B). Fasting blood samples were taken at study baseline and after 12-week intervention to determine related markers. Results: After 12. weeks of intervention, compared with the placebo, vitamin D supplementation resulted in a significant reduction in ulcer length (-2.1. ±. 1.1 vs. -1.1. ±. 1.1. cm, P = 0.001), width (-2.0. ±. 1.2 vs. -1.1. ±. 1.0. cm, P = 0.02) and depth (-1.0. ±. 0.5 vs. -0.5. ±. 0.5. cm, P. <. 0.001), and erythema rate (100 vs. 80, P = 0.01). In addition, in supplemented patients changes in serum insulin concentration (-3.4. ±. 9.2 vs + 2.8. ±. 9.3 μIU/mL, P = 0.01), homeostasis model of assessment-estimated insulin resistance (-1.5. ±. 4.1 vs + 1.7. ±. 5.1, P = 0.01), the quantitative insulin sensitivity check index (+. 0.006. ±. 0.02 vs. -0.006. ±. 0.02, P = 0.03) and HbA1c (-0.6. ±. 0.6 vs. -0.1. ±. 0.5, P = 0.004) were significantly different from those of patients in the placebo group. Additionally, following supplementation with vitamin D, significant reductions in serum total- (-15.8. ±. 18.9 vs + 5.3. ±. 31.8. mg/dL, P = 0.003), LDL- (-17.2. ±. 19.8 vs + 2.2. ±. 28.6. mg/dL, P = 0.003), total-/HDL-cholesterol ratio (-1.1. ±. 0.8 vs. -0.2. ±. 1.1, P = 0.001), high sensitivity C-reactive protein (hs-CRP) (-0.4. ±. 2.5 vs + 1.9. ±. 4.2. μg/mL, P = 0.01), erythrocyte sedimentation rate (ESR) (-34.7. ±. 32.4 vs. -18.0. ±. 26.6. mm/h, P = 0.03) and plasma malondialdehyde (MDA) concentrations (-0.7. ±. 0.9 vs. -0.2. ±. 0.5. μmol/L, P = 0.008) were seen compared with the placebo. Conclusions: Overall, vitamin D supplementation for 12. weeks among patients with DFU had beneficial effects on glucose homeostasis, total-, LDL-, total-/HDL-cholesterol, ESR, hs-CRP and MDA levels. In addition, vitamin D may have played an indirect role in wound healing due to its effect on improved glycemic control. © 2016 Elsevier Inc.

Item Type: Article
Additional Information: cited By 0; Article in Press
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 22:16
Last Modified: 08 Mar 2017 22:16
URI: http://eprints.kaums.ac.ir/id/eprint/153

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