Effects of aqueous extract of Holothuria arenicola and low frequency electromagnetic field on serum insulin, glucose and beta-amyloid (Aβ1-42) in diabetic rats

Sadoughi, S.D. and Chamipa, M. (2016) Effects of aqueous extract of Holothuria arenicola and low frequency electromagnetic field on serum insulin, glucose and beta-amyloid (Aβ1-42) in diabetic rats. Feyz Journal of Kashan University of Medical Sciences, 20.

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Official URL: http://feyz.kaums.ac.ir/article-1-2964-en.html
DOI: UNSPECIFIED

Abstract

Background: Beta-amyloid is increased in the brain of diabetic patients. Considering different effects of electromagnetic field on biological processes, this study was performed to investigate the concomitant effects of aqueous extract of Holothuria arenicola and low frequency electromagnetic field (EMF) on the serum insulin, glucose and amyloid beta level in diabetic rats. Materials and Methods: In this experimental study, 42 male rats were divided into 7 equal groups: control and diabetic control (distilled water); diabetic 1(100 mg/kg of extract); diabetic 2 (100 mg/kg of extract + EMF 10 gauss); diabetic 3 (100 mg/kg of extract + EMF400); diabetic 4 (EMF10); diabetic 5 (EMF400). Diabetes was induced by intra-peritoneal injection of Alloxan. Diabetic groups 2, 3, 4 and 5 had daily exposure to the EMF for 60 minutes. The serum levels of insulin, blood glucose and beta-amyloid protein were measured at first, fifteenth and thirtieth days. Results: The serum glucose, insulin and beta-amyloid level for diabetic samples 1 and 2 at first, fifteenth and thirtieth days were significant compared to the diabetic control. At fifteenth and thirtieth days, glucose and insulin level for diabetic 3 and 4 samples were significant compared to the diabetic control (P<0.05). The beta-amyloid for diabetic 4 samples was significant at thirtieth day. At fifteenth and thirtieth days, a significant increase and decrease in glucose, insulin and beta-amyloid was seen, respectively in diabetic 5 compared to diabetic control (P<0.05). Conclusion: Injecting Holothuria arenicola extract to the diabetic rats results in a decrease and increase in glucose, insulin and beta-amyloid, respectively. These effects were augmented with the simultaneous use of 10 gauss electromagnetic field.

Item Type: Article
Subjects: Medicine
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 07 May 2017 11:52
Last Modified: 23 May 2017 14:23
URI: http://eprints.kaums.ac.ir/id/eprint/1498

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