Determination of hepatitis B surface antibody and gamma interferon responsiveness in vaccinated personnel reffered to a health network in Dashte-e Azadegan (Khozestan province)

Heidari, S. and Rezatofighi, S.E. and Roayaei-Ardakani, M. and Akhond, M.R. (2016) Determination of hepatitis B surface antibody and gamma interferon responsiveness in vaccinated personnel reffered to a health network in Dashte-e Azadegan (Khozestan province). Feyz Journal of Kashan University of Medical Sciences, 20.

Full text not available from this repository.
Official URL: http://feyz.kaums.ac.ir/article-1-3090-en.html
DOI: UNSPECIFIED

Abstract

Background: Among the preventing measures for hepatitis B is vaccination against the virus. This study aimed to determine the antibody level against the hepatitis B surface antigen (anti-HBs) and its relation to interferon gamma (IFN-γ) level among the vaccinated staffs and also the reasons for the lack of response in such persons. Materials and Methods: This cross-sectional study was done on vaccinated staff (n=130) referred to Shahid Chamran Hospital. Using ELISA the samples were studied for anti-HBsAb and INF-γ level. Then, the relationship between antibody level and some indexes (e.g. sex, age, BMI, number of vaccine doses, time past after the last dose and INF-γ level) was considered. Results: Among the studied participants, 68.5 and 31.5 had a perfect and failure of immunity response (>10 IU/ml and <10 IU/ml, respectively). There was a direct relationship between the INF-γ and anti-HBs titration (R=0.635). In addition, there was a significant relationship (P<0.05) between anti-HBs titer and some indexes (e.g. BMI, the number of doses and the time interval since the last dose of vaccine); however, no significant relationship was observed between the sex and age on one hand and antibody titration on the other hand. Conclusion: Failure in INF-γ production against the virus can have a role in immunity response. Hence, measuring the anti-HBs level following the vaccination and also 5 years after are suggested for high risk cases; then, upon which a decision can be made on the reminder dosage.

Item Type: Article
Subjects: Immunology and Microbiology
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 06 May 2017 15:36
Last Modified: 22 May 2017 18:07
URI: http://eprints.kaums.ac.ir/id/eprint/1484

Actions (login required)

View Item View Item