The presence of Helicobacter pylori in gallbladder mucosa of patients with chronic cholecystitis

Kheirmand, F. and Valadi, F. and Dolatshahi, K. (2016) The presence of Helicobacter pylori in gallbladder mucosa of patients with chronic cholecystitis. Feyz Journal of Kashan University of Medical Sciences, 20.

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Official URL: http://feyz.kaums.ac.ir/article-1-3180-en.html
DOI: UNSPECIFIED

Abstract

Background: Helicobacter pylori (H. pylori) has infected over half of the world’s population. Among the long-term outcomes of H.pylori infection is gastric malignancies, particularly gastric cancer and gastric mucosa-associated tissue (MALT) lymphoma. In recent years, the attention has been drawn to the possible association of H. pylori infections not only with gastric and duodenal disorders but also with several gastrointestinal diseases (e.g. liver and biliary diseases). H. pylori have recently found to be associated with some diseases of the biliary tree. Earlier reports on the detection of H. pylori in the gallbladder mucosa of patients with biliary disease have shown contradictory results which requires further studies. The aim of this cross-sectional study was to determine the presence of H. pylori in gallbladder mucosa of patients with a diagnosis of chronic cholecystitis using histological study of surgical gallbladder specimens. Materials and Methods: In the present study, gallbladder samples (total no=70) from patients with chronic cholecystitis were collected at Shariati hospital (Isfahan, Iran) from February to April 2015. Giemsa staining was used to detect H. pylori in gallbladder mucosa. Results: Using Giemsa staining in 18 (25.7) out of 70 patients gallbladder mucosa were positive for H. pylori. There was an association between the presence of H. pylori in the gallbladder mucosa and chronic cholecystitis. (P<0.001) Conclusion: H. pylori can be detected in gallbladder mucosa of patients with chronic cholecystitis. Further studies are needed to support these findings.

Item Type: Article
Subjects: Immunology and Microbiology
Divisions: Feyz journal
Depositing User: ART . editor
Date Deposited: 06 May 2017 15:06
Last Modified: 24 May 2017 19:03
URI: http://eprints.kaums.ac.ir/id/eprint/1456

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