Prevalence and trends of transfusion-Transmissible viral infections among blood donors in south of Iran: An Eleven-Year retrospective study

Farshadpour, F. and Taherkhani, R. and Tajbakhsh, S. and Tangestani, M.G. and Hajiani, G. and Sharifi, N. and Taherkhani, S. and Nejadbolkheyr, A. (2016) Prevalence and trends of transfusion-Transmissible viral infections among blood donors in south of Iran: An Eleven-Year retrospective study. PLoS ONE, 11 (6).

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Abstract

Background Blood transfusion is considered a potential risk factor for transmission of life-threatening viral infections, including HIV, HCV and HBV infections. This study was performed to find out the prevalence and trends of these infections among blood donors in Southern Iran. Methods The blood donor data recorded in twelve regional blood transfusion centers from 2004 to 2014 were analyzed in an anonymous way with respect to the results of serological screening for HBV, HCV, and HIV infections. Overall, 293454 donors were screened for viral infections. Results Most of the donors were male, married, aged between 20-40 years, educated, and regular donors. The overall seroprevalence rates of HBV, HCV and HIV were 0.15, 0.1 and 0.004, respectively. The highest seroprevalence was found for HBV, followed by HCV and HIV. These infections were more prevalent in male, low educated and first time donors. The highest HCV seroprevalence was observed among donors aged 20 to 40 years, while HBV seroprevalence increased with age. The seroprevalence rates of HBV and HCV from 2004 to 2014 showed significant decreasing trends from 0.460 to 0.060 (P < 0.001) and 0.329 to 0.045 (P < 0.001), respectively. Whereas HIV infection had a slight but not significant decline from 0.0173 in 2004 to 0.0028 in 2014 (P = 0.087). Conclusions The decreasing trends of transfusion-transmissible viral infections in blood donations indicate that the attempts of IBTO were successful in improving the safety of the blood supply, since the prevalence rates of viral infections have been reduced to very low levels in blood donations over the years. However, still more effective techniques such as polymerase chain reaction (PCR) are needed to guarantee blood safety. © 2016 Farshadpour et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: adult; age; Article; blood donor; blood safety; blood transfusion; descriptive research; educational status; female; Hepatitis B virus; Hepatitis C virus; human; Human immunodeficiency virus; Iran; male; prevalence; retrospective study; serology; seroprevalence; sex difference; trend study; virus transmission
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 22:47
Last Modified: 08 Mar 2017 22:47
URI: http://eprints.kaums.ac.ir/id/eprint/140

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