Association between PAPP-A and placental thickness

Mesdaghinia, E. and Behrashi, M. and Saeidi, A. and Kalahroodi, M.A. and Sehat, M. (2016) Association between PAPP-A and placental thickness. International Journal of Reproductive BioMedicine, 14 (6). pp. 421-426.

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Abstract

Background: Measuring of maternal serum pregnancy-associated plasma protein-A (PAPP-A) in first trimester can be a way for early detection of adverse prenatal outcome due to faulty placenta. Objective: The aim was to Determination of association between placental thickness in second trimester with low level of PAPP-A in first trimester. Materials and Methods: In this cohort study, serum PAPP-A of 187 pregnant women was measured in the first trimester of pregnancy. Patients who had PAPP-A �0.8 MOM were in exposed and others who had PAPP-A >0.8 defined as unexposed group. The criteria of placental thickness in ultrasound study was thickness of 4 cm or more than 50 of placental length. Results: Of 187 patients, 87 patients had PAPP-A >0.8 and 93 patients had PAPP-A �0.8. Women with low levels of PAPP-A in the first trimester, had an increased incidence placental thickness of 34.4, whereas another group had about 15 (p=0.002). Also, PAPP-A levels had acceptable sensitivity and specificity for placental thickness detection (71.1 and 54.8, respectively. Conclusion: Our study showed that serum level of PAPP-A generally was low (�0.8) in women with a thick placenta (>4 cm or >50 of placental length). The first trimester of pregnancy measurement of PAPP-A will be more predictable for healthy placenta. © 2016, Research and Clinical Center for Infertitlity. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: pregnancy associated plasma protein A, adult; Article; cohort analysis; controlled study; diagnostic test accuracy study; enzyme linked immunosorbent assay; female; fetus echography; first trimester pregnancy; functions of embryonic, fetal and placental structures; human; morphometrics; placenta thickness; predictive value; pregnant woman; second trimester pregnancy; sensitivity and specificity
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of , Obstetrics & Gynecology
Depositing User: editor . 2
Date Deposited: 05 Mar 2017 21:10
Last Modified: 05 Mar 2017 21:10
URI: http://eprints.kaums.ac.ir/id/eprint/130

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